Cell atlas - ELAC2 - The Human Protein Atlas

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ELAC2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS siRNA

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ELAC2
Gene description	ElaC ribonuclease Z 2
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
siRNA	The location(s) are Validated based on siRNA mediated gene silencing.

DATA RELIABILITY
Reliability score	Validated based on 1 antibody. HPA019535
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ASSAYS

RNA expression

Human cells

siRNA

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA019535	A-431	Nucleoplasm
HPA019535	U-2 OS	Nucleoplasm
HPA019535	U-251 MG	Nucleoplasm

siRNA VALIDATION

Relative fluorescence intensity (RFI)

Antibody

HPA019535

siRNA validation

Validated: Significant downregulation > 25% by both siRNA:s.

Analysis performed in

Nuclear region of segmented cells in 10x-images

siRNA 1

siRNA 2

RFI

27%

36%

p-value

< 0.01


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Sample	Cell line
HPA019535	siRNA 1	U-2 OS
HPA019535	siRNA 2	U-2 OS
HPA019535	scrambled	U-2 OS

GENE INFORMATION
Gene name	ELAC2 (HGNC Symbol)
Synonyms	FLJ10530, HPC2
Description	ElaC ribonuclease Z 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Chromosome	17
Cytoband	p12
Chromosome location (bp)	12992391 - 13018187
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000006744 (version 83.38)
Entrez gene	60528
UniProt	Q9BQ52 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BQ52
Antibodypedia	ELAC2 antibodies

PROTEIN BROWSER

ELAC2-001	ELAC2-002	ELAC2-007	ELAC2-012	ELAC2-013	ELAC2-015	ELAC2-016	ELAC2-017	ELAC2-020	ELAC2-021	ELAC2-022

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ELAC2-001 ENSP00000337445 ENST00000338034	Q9BQ52 [Direct mapping] Zinc phosphodiesterase ELAC protein 2 Show all	Enzymes ENZYME proteins Hydrolases Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0008033 [tRNA processing] GO:0010467 [gene expression] GO:0042645 [mitochondrial nucleoid] GO:0042781 [3'-tRNA processing endoribonuclease activity] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] GO:0072684 [mitochondrial tRNA 3'-trailer cleavage, endonucleolytic] Show all	826 aa 92.2 kDa	No	0
ELAC2-002 ENSP00000379291 ENST00000395962	G5E9D5 [Direct mapping] ElaC homolog 2 (E. coli), isoform CRA_a; Zinc phosphodiesterase ELAC protein 2 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0034414 [tRNA 3'-trailer cleavage, endonucleolytic] GO:0042781 [3'-tRNA processing endoribonuclease activity] Show all	807 aa 90 kDa	No	0
ELAC2-007 ENSP00000406192 ENST00000446899	H7C2I4 [Direct mapping] Zinc phosphodiesterase ELAC protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0034414 [tRNA 3'-trailer cleavage, endonucleolytic] GO:0042781 [3'-tRNA processing endoribonuclease activity] Show all	286 aa 31.7 kDa	No	0
ELAC2-012 ENSP00000405223 ENST00000426905	Q9BQ52 [Direct mapping] Zinc phosphodiesterase ELAC protein 2 Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0008033 [tRNA processing] GO:0010467 [gene expression] GO:0042781 [3'-tRNA processing endoribonuclease activity] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] GO:0072684 [mitochondrial tRNA 3'-trailer cleavage, endonucleolytic] Show all	786 aa 87.6 kDa	No	0
ELAC2-013 ENSP00000463740 ENST00000584650	E7ES68 [Direct mapping] Zinc phosphodiesterase ELAC protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0034414 [tRNA 3'-trailer cleavage, endonucleolytic] GO:0042781 [3'-tRNA processing endoribonuclease activity] Show all	626 aa 70.1 kDa	No	0
ELAC2-015 ENSP00000477482 ENST00000578071	V9GZ72 [Direct mapping] Zinc phosphodiesterase ELAC protein 2 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008033 [tRNA processing] GO:0034414 [tRNA 3'-trailer cleavage, endonucleolytic] GO:0042781 [3'-tRNA processing endoribonuclease activity] Show all	158 aa 17.5 kDa	No	0
ELAC2-016 ENSP00000464358 ENST00000583371	J3QRS2 [Direct mapping] Zinc phosphodiesterase ELAC protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0034414 [tRNA 3'-trailer cleavage, endonucleolytic] GO:0042781 [3'-tRNA processing endoribonuclease activity] Show all	122 aa 13.9 kDa	No	0
ELAC2-017 ENSP00000463321 ENST00000581499	J3QL08 [Direct mapping] Zinc phosphodiesterase ELAC protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0034414 [tRNA 3'-trailer cleavage, endonucleolytic] GO:0042781 [3'-tRNA processing endoribonuclease activity] Show all	132 aa 15 kDa	No	0
ELAC2-020 ENSP00000463594 ENST00000580504	J3QLK4 [Direct mapping] Zinc phosphodiesterase ELAC protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0034414 [tRNA 3'-trailer cleavage, endonucleolytic] GO:0042781 [3'-tRNA processing endoribonuclease activity] Show all	148 aa 16.5 kDa	No	0
ELAC2-021 ENSP00000477044 ENST00000609101	V9GYS7 [Direct mapping] Zinc phosphodiesterase ELAC protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0034414 [tRNA 3'-trailer cleavage, endonucleolytic] GO:0042781 [3'-tRNA processing endoribonuclease activity] Show all	242 aa 26.8 kDa	No	0
ELAC2-022 ENSP00000477093 ENST00000609757	V9GYU5 [Direct mapping] Zinc phosphodiesterase ELAC protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0034414 [tRNA 3'-trailer cleavage, endonucleolytic] GO:0042781 [3'-tRNA processing endoribonuclease activity] Show all	124 aa 14.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.