Cell atlas - CD79B - The Human Protein Atlas

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CD79B

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm
	Plasma membrane

Human cell
	Cytosol
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	CD79B
Gene description	CD79b molecule, immunoglobulin-associated beta
Protein class	Cancer-related genes CD markers Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane, cytosol & nucleoplasm.
RNA cell category	Group enriched (U-698, Daudi, REH)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (uncertain), Plasma membrane (uncertain), Cytosol (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA009178
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (U-698, Daudi, REH) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane, cytosol & nucleoplasm.

Main location

Nucleoplasm (uncertain), Plasma membrane (uncertain), Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA009178	A-431	Nucleoplasm
			Golgi apparatus
			Plasma membrane
			Cytosol
	HPA009178	U-2 OS	Nucleoplasm
			Plasma membrane
			Cytosol
	HPA009178	U-251 MG	Nucleoplasm
			Plasma membrane
			Cytosol

GENE INFORMATION
Gene name	CD79B (HGNC Symbol)
Synonyms	B29, IGB
Description	CD79b molecule, immunoglobulin-associated beta (HGNC Symbol)
Entrez gene summary	The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q23.3
Chromosome location (bp)	63928740 - 63932354
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000007312 (version 83.38)
Entrez gene	974
UniProt	P40259 (UniProt - Evidence at protein level)
neXtProt	NX_P40259
Antibodypedia	CD79B antibodies

PROTEIN BROWSER

CD79B-001	CD79B-002	CD79B-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD79B-001 ENSP00000006750 ENST00000006750	P40259 [Direct mapping] B-cell antigen receptor complex-associated protein beta chain Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002250 [adaptive immune response] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0016020 [membrane] GO:0070062 [extracellular exosome] Show all	229 aa 26 kDa	Yes	1
CD79B-002 ENSP00000376544 ENST00000392795	P40259 [Direct mapping] B-cell antigen receptor complex-associated protein beta chain Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002250 [adaptive immune response] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0009897 [external side of plasma membrane] GO:0016020 [membrane] GO:0019815 [B cell receptor complex] GO:0050853 [B cell receptor signaling pathway] GO:0070062 [extracellular exosome] Show all	230 aa 26.1 kDa	Yes	1
CD79B-004 ENSP00000245862 ENST00000349817	P40259 [Direct mapping] B-cell antigen receptor complex-associated protein beta chain Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002250 [adaptive immune response] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0016020 [membrane] GO:0070062 [extracellular exosome] Show all	125 aa 14 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.