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PAX6

GENERAL INFORMATION

Gene name

 PAX6

Gene description

 Paired box 6

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 15
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (cerebral cortex, stomach)
GTEx:Tissue enriched (cerebellum)
FANTOM5:Tissue enhanced (cerebellum, retina)

Protein evidence

 Evidence at protein level

Protein expression

 Distinct nuclear expression in cerebellar granular layer, islets of Langerhans and subsets of endocrine cells in gastrointestinal tract.

DATA RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. External RNA characterization data supports antibody staining.

Reliability score

 Supported based on 2 antibodies.
HPA030775 , CAB034143
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebral cortex, stomach)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum, retina)

GENE INFORMATION

Gene name

 PAX6 (HGNC Symbol)

Synonyms

 AN, AN2, D11S812E, WAGR

Description

 Paired box 6 (HGNC Symbol)

Entrez gene summary

 This gene encodes a homeobox and paired domain-containing protein that binds DNA and functions as a regulator of transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. This gene is regulated by multiple enhancers located up to hundreds of kilobases distant from this locus. Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]

Chromosome

 11

Cytoband

 p13

Chromosome location (bp)

 31784792 - 31817961

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000007372 (version 83.38)

Entrez gene

 5080

UniProt

 P26367 (UniProt - Evidence at protein level)

neXtProt

 NX_P26367

Antibodypedia

 PAX6 antibodies

PROTEIN BROWSER
«
PAX6-001
PAX6-002
PAX6-003
PAX6-004
PAX6-005
PAX6-008
PAX6-009
PAX6-011
PAX6-012
PAX6-013
PAX6-016
PAX6-020
PAX6-021
PAX6-201
PAX6-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PAX6-001
ENSP00000368410
ENST00000379115
P26367 [Direct mapping]
Paired box protein Pax-6
F1T0F8 [Target identity:100%; Query identity:100%]
Paired box protein Pax-6
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001568 [blood vessel development]
GO:0001654 [eye development]
GO:0003322 [pancreatic A cell development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007417 [central nervous system development]
GO:0007601 [visual perception]
GO:0008134 [transcription factor binding]
GO:0009611 [response to wounding]
GO:0009887 [organ morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0016567 [protein ubiquitination]
GO:0019901 [protein kinase binding]
GO:0035035 [histone acetyltransferase binding]
GO:0042593 [glucose homeostasis]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048663 [neuron fate commitment]
GO:0050768 [negative regulation of neurogenesis]
GO:0061072 [iris morphogenesis]
GO:0061303 [cornea development in camera-type eye]
GO:0070412 [R-SMAD binding]
Show all
 436 aa
48.2 kDa 		No 0
PAX6-002
ENSP00000241001
ENST00000241001
P26367 [Direct mapping]
Paired box protein Pax-6
Q66SS1 [Target identity:100%; Query identity:100%]
Paired box gene 6 isoform a
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001568 [blood vessel development]
GO:0001654 [eye development]
GO:0003322 [pancreatic A cell development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007417 [central nervous system development]
GO:0007601 [visual perception]
GO:0008134 [transcription factor binding]
GO:0009611 [response to wounding]
GO:0009887 [organ morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0016567 [protein ubiquitination]
GO:0019901 [protein kinase binding]
GO:0035035 [histone acetyltransferase binding]
GO:0042593 [glucose homeostasis]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048663 [neuron fate commitment]
GO:0050768 [negative regulation of neurogenesis]
GO:0061072 [iris morphogenesis]
GO:0061303 [cornea development in camera-type eye]
GO:0070412 [R-SMAD binding]
Show all
 422 aa
46.7 kDa 		No 0
PAX6-003
ENSP00000368418
ENST00000379123
P26367 [Direct mapping]
Paired box protein Pax-6
Q66SS1 [Target identity:100%; Query identity:100%]
Paired box gene 6 isoform a
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001568 [blood vessel development]
GO:0001654 [eye development]
GO:0003322 [pancreatic A cell development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007417 [central nervous system development]
GO:0007601 [visual perception]
GO:0008134 [transcription factor binding]
GO:0009611 [response to wounding]
GO:0009887 [organ morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0016567 [protein ubiquitination]
GO:0019901 [protein kinase binding]
GO:0035035 [histone acetyltransferase binding]
GO:0042593 [glucose homeostasis]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048663 [neuron fate commitment]
GO:0050768 [negative regulation of neurogenesis]
GO:0061072 [iris morphogenesis]
GO:0061303 [cornea development in camera-type eye]
GO:0070412 [R-SMAD binding]
Show all
 422 aa
46.7 kDa 		No 0
PAX6-004
ENSP00000368403
ENST00000379109
P26367 [Direct mapping]
Paired box protein Pax-6
Q66SS1 [Target identity:100%; Query identity:100%]
Paired box gene 6 isoform a
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001568 [blood vessel development]
GO:0001654 [eye development]
GO:0003322 [pancreatic A cell development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007417 [central nervous system development]
GO:0007601 [visual perception]
GO:0008134 [transcription factor binding]
GO:0009611 [response to wounding]
GO:0009887 [organ morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0016567 [protein ubiquitination]
GO:0019901 [protein kinase binding]
GO:0035035 [histone acetyltransferase binding]
GO:0042593 [glucose homeostasis]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048663 [neuron fate commitment]
GO:0050768 [negative regulation of neurogenesis]
GO:0061072 [iris morphogenesis]
GO:0061303 [cornea development in camera-type eye]
GO:0070412 [R-SMAD binding]
Show all
 422 aa
46.7 kDa 		No 0
PAX6-005
ENSP00000368406
ENST00000379111
P26367 [Direct mapping]
Paired box protein Pax-6
Q66SS1 [Target identity:100%; Query identity:100%]
Paired box gene 6 isoform a
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001568 [blood vessel development]
GO:0001654 [eye development]
GO:0003322 [pancreatic A cell development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007417 [central nervous system development]
GO:0007601 [visual perception]
GO:0008134 [transcription factor binding]
GO:0009611 [response to wounding]
GO:0009887 [organ morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0016567 [protein ubiquitination]
GO:0019901 [protein kinase binding]
GO:0035035 [histone acetyltransferase binding]
GO:0042593 [glucose homeostasis]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048663 [neuron fate commitment]
GO:0050768 [negative regulation of neurogenesis]
GO:0061072 [iris morphogenesis]
GO:0061303 [cornea development in camera-type eye]
GO:0070412 [R-SMAD binding]
Show all
 422 aa
46.7 kDa 		No 0
PAX6-008
ENSP00000368427
ENST00000379132
P26367 [Direct mapping]
Paired box protein Pax-6
Q66SS1 [Target identity:100%; Query identity:100%]
Paired box gene 6 isoform a
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001568 [blood vessel development]
GO:0001654 [eye development]
GO:0003322 [pancreatic A cell development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007417 [central nervous system development]
GO:0007601 [visual perception]
GO:0008134 [transcription factor binding]
GO:0009611 [response to wounding]
GO:0009887 [organ morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0016567 [protein ubiquitination]
GO:0019901 [protein kinase binding]
GO:0035035 [histone acetyltransferase binding]
GO:0042593 [glucose homeostasis]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048663 [neuron fate commitment]
GO:0050768 [negative regulation of neurogenesis]
GO:0061072 [iris morphogenesis]
GO:0061303 [cornea development in camera-type eye]
GO:0070412 [R-SMAD binding]
Show all
 422 aa
46.7 kDa 		No 0
PAX6-009
ENSP00000368424
ENST00000379129
P26367 [Direct mapping]
Paired box protein Pax-6
F1T0F8 [Target identity:100%; Query identity:100%]
Paired box protein Pax-6
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001568 [blood vessel development]
GO:0001654 [eye development]
GO:0003322 [pancreatic A cell development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007417 [central nervous system development]
GO:0007601 [visual perception]
GO:0008134 [transcription factor binding]
GO:0009611 [response to wounding]
GO:0009887 [organ morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0016567 [protein ubiquitination]
GO:0019901 [protein kinase binding]
GO:0035035 [histone acetyltransferase binding]
GO:0042593 [glucose homeostasis]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048663 [neuron fate commitment]
GO:0050768 [negative regulation of neurogenesis]
GO:0061072 [iris morphogenesis]
GO:0061303 [cornea development in camera-type eye]
GO:0070412 [R-SMAD binding]
Show all
 436 aa
48.2 kDa 		No 0
PAX6-011
ENSP00000368401
ENST00000379107
P26367 [Direct mapping]
Paired box protein Pax-6
F1T0F8 [Target identity:100%; Query identity:100%]
Paired box protein Pax-6
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001568 [blood vessel development]
GO:0001654 [eye development]
GO:0003322 [pancreatic A cell development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007417 [central nervous system development]
GO:0007601 [visual perception]
GO:0008134 [transcription factor binding]
GO:0009611 [response to wounding]
GO:0009887 [organ morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0016567 [protein ubiquitination]
GO:0019901 [protein kinase binding]
GO:0035035 [histone acetyltransferase binding]
GO:0042593 [glucose homeostasis]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048663 [neuron fate commitment]
GO:0050768 [negative regulation of neurogenesis]
GO:0061072 [iris morphogenesis]
GO:0061303 [cornea development in camera-type eye]
GO:0070412 [R-SMAD binding]
Show all
 436 aa
48.2 kDa 		No 0
PAX6-012
ENSP00000388132
ENST00000423822
B1B1I9 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
Show all
 62 aa
6.7 kDa 		No 0
PAX6-013
ENSP00000404356
ENST00000438681
B1B1I8 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
Show all
 39 aa
4.2 kDa 		No 0
PAX6-016
ENSP00000397384
ENST00000455099
B1B1J0 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
Show all
 124 aa
13.4 kDa 		No 0
PAX6-020
ENSP00000436365
ENST00000525535
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 2 aa
0.3 kDa 		No 0
PAX6-021
ENSP00000431585
ENST00000524853
E9PKM0 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
Show all
 58 aa
6.1 kDa 		No 0
PAX6-201
ENSP00000404100
ENST00000419022
P26367 [Direct mapping]
Paired box protein Pax-6
F1T0F8 [Target identity:100%; Query identity:100%]
Paired box protein Pax-6
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000132 [establishment of mitotic spindle orientation]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001568 [blood vessel development]
GO:0001654 [eye development]
GO:0001709 [cell fate determination]
GO:0001764 [neuron migration]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0002088 [lens development in camera-type eye]
GO:0003309 [type B pancreatic cell differentiation]
GO:0003322 [pancreatic A cell development]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007224 [smoothened signaling pathway]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0007417 [central nervous system development]
GO:0007420 [brain development]
GO:0007435 [salivary gland morphogenesis]
GO:0007601 [visual perception]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0009611 [response to wounding]
GO:0009786 [regulation of asymmetric cell division]
GO:0009887 [organ morphogenesis]
GO:0009950 [dorsal/ventral axis specification]
GO:0009952 [anterior/posterior pattern specification]
GO:0009953 [dorsal/ventral pattern formation]
GO:0010468 [regulation of gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0016567 [protein ubiquitination]
GO:0019901 [protein kinase binding]
GO:0021543 [pallium development]
GO:0021778 [oligodendrocyte cell fate specification]
GO:0021796 [cerebral cortex regionalization]
GO:0021797 [forebrain anterior/posterior pattern specification]
GO:0021798 [forebrain dorsal/ventral pattern formation]
GO:0021902 [commitment of neuronal cell to specific neuron type in forebrain]
GO:0021905 [forebrain-midbrain boundary formation]
GO:0021912 [regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification]
GO:0021913 [regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification]
GO:0021918 [regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment]
GO:0021978 [telencephalon regionalization]
GO:0021983 [pituitary gland development]
GO:0023019 [signal transduction involved in regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0030216 [keratinocyte differentiation]
GO:0030334 [regulation of cell migration]
GO:0030858 [positive regulation of epithelial cell differentiation]
GO:0030900 [forebrain development]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032808 [lacrimal gland development]
GO:0033365 [protein localization to organelle]
GO:0035035 [histone acetyltransferase binding]
GO:0042462 [eye photoreceptor cell development]
GO:0042593 [glucose homeostasis]
GO:0043010 [camera-type eye development]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045165 [cell fate commitment]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048505 [regulation of timing of cell differentiation]
GO:0048596 [embryonic camera-type eye morphogenesis]
GO:0048663 [neuron fate commitment]
GO:0048708 [astrocyte differentiation]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0050767 [regulation of neurogenesis]
GO:0050768 [negative regulation of neurogenesis]
GO:0060041 [retina development in camera-type eye]
GO:0061072 [iris morphogenesis]
GO:0061303 [cornea development in camera-type eye]
GO:0070410 [co-SMAD binding]
GO:0070412 [R-SMAD binding]
GO:0071837 [HMG box domain binding]
GO:2000178 [negative regulation of neural precursor cell proliferation]
Show all
 436 aa
48.2 kDa 		No 0
PAX6-202
ENSP00000480026
ENST00000606377
P26367 [Direct mapping]
Paired box protein Pax-6
F1T0F8 [Target identity:100%; Query identity:100%]
Paired box protein Pax-6
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001568 [blood vessel development]
GO:0001654 [eye development]
GO:0003322 [pancreatic A cell development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007417 [central nervous system development]
GO:0007601 [visual perception]
GO:0008134 [transcription factor binding]
GO:0009611 [response to wounding]
GO:0009887 [organ morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0016567 [protein ubiquitination]
GO:0019901 [protein kinase binding]
GO:0035035 [histone acetyltransferase binding]
GO:0042593 [glucose homeostasis]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048663 [neuron fate commitment]
GO:0050768 [negative regulation of neurogenesis]
GO:0061072 [iris morphogenesis]
GO:0061303 [cornea development in camera-type eye]
GO:0070412 [R-SMAD binding]
Show all
 436 aa
48.2 kDa 		No 0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.