Expression of MGST1 in cancer - Summary

CANCER ATLAS

Gene description

Microsomal glutathione S-transferase 1

Protein class

Enzymes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA044840

GENE INFORMATION
Gene name	MGST1 (HGNC Symbol)
Synonyms	GST12, MGST-I
Description	Microsomal glutathione S-transferase 1 (HGNC Symbol)
Entrez gene summary	The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]
Chromosome	12
Cytoband	p12.3
Chromosome location (bp)	16347142 - 16609259
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000008394 (version 83.38)
Entrez gene	4257
UniProt	P10620 (UniProt - Evidence at protein level)
neXtProt	NX_P10620
Antibodypedia	MGST1 antibodies

PROTEIN BROWSER

MGST1-001	MGST1-002	MGST1-004	MGST1-005	MGST1-006	MGST1-007	MGST1-009	MGST1-013	MGST1-201	MGST1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MGST1-001 ENSP00000379513 ENST00000396210	P10620 [Direct mapping] Microsomal glutathione S-transferase 1 A0A024RAX2 [Target identity:100%; Query identity:100%] Microsomal glutathione S-transferase 1, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0004602 [glutathione peroxidase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005778 [peroxisomal membrane] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006805 [xenobiotic metabolic process] GO:0016021 [integral component of membrane] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070207 [protein homotrimerization] GO:0071449 [cellular response to lipid hydroperoxide] GO:1901687 [glutathione derivative biosynthetic process] Show all	155 aa 17.6 kDa	No	4
MGST1-002 ENSP00000379510 ENST00000396207	P10620 [Direct mapping] Microsomal glutathione S-transferase 1 A0A024RAX2 [Target identity:100%; Query identity:100%] Microsomal glutathione S-transferase 1, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0004602 [glutathione peroxidase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005778 [peroxisomal membrane] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006805 [xenobiotic metabolic process] GO:0016021 [integral component of membrane] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070207 [protein homotrimerization] GO:0071449 [cellular response to lipid hydroperoxide] GO:1901687 [glutathione derivative biosynthetic process] Show all	155 aa 17.6 kDa	No	4
MGST1-004 ENSP00000438308 ENST00000535309	P10620 [Direct mapping] Microsomal glutathione S-transferase 1 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0004602 [glutathione peroxidase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005778 [peroxisomal membrane] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006805 [xenobiotic metabolic process] GO:0016021 [integral component of membrane] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070207 [protein homotrimerization] GO:0071449 [cellular response to lipid hydroperoxide] GO:1901687 [glutathione derivative biosynthetic process] Show all	87 aa 10 kDa	No	1
MGST1-005 ENSP00000442557 ENST00000536371	F5H7F6 [Direct mapping] Microsomal glutathione S-transferase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	77 aa 8.9 kDa	No	1
MGST1-006 ENSP00000442970 ENST00000540126	F5H6X2 [Direct mapping] Microsomal glutathione S-transferase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	80 aa 9.2 kDa	No	1
MGST1-007 ENSP00000437988 ENST00000540056	F5H613 [Direct mapping] Microsomal glutathione S-transferase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	46 aa 5.3 kDa	No	1
MGST1-009 ENSP00000440443 ENST00000538885	F5GX73 [Direct mapping] Microsomal glutathione S-transferase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	42 aa 4.8 kDa	No	1
MGST1-013 ENSP00000442767 ENST00000543076	F5H760 [Direct mapping] Microsomal glutathione S-transferase 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		106 aa 11.9 kDa	No	0
MGST1-201 ENSP00000010404 ENST00000010404	P10620 [Direct mapping] Microsomal glutathione S-transferase 1 A0A024RAX2 [Target identity:100%; Query identity:100%] Microsomal glutathione S-transferase 1, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0004602 [glutathione peroxidase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005778 [peroxisomal membrane] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006805 [xenobiotic metabolic process] GO:0016021 [integral component of membrane] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070207 [protein homotrimerization] GO:0071449 [cellular response to lipid hydroperoxide] GO:1901687 [glutathione derivative biosynthetic process] Show all	155 aa 17.6 kDa	No	4
MGST1-202 ENSP00000379512 ENST00000396209	P10620 [Direct mapping] Microsomal glutathione S-transferase 1 A0A024RAX2 [Target identity:100%; Query identity:100%] Microsomal glutathione S-transferase 1, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0004602 [glutathione peroxidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005743 [mitochondrial inner membrane] GO:0005778 [peroxisomal membrane] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006749 [glutathione metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0010243 [response to organonitrogen compound] GO:0016021 [integral component of membrane] GO:0032496 [response to lipopolysaccharide] GO:0033327 [Leydig cell differentiation] GO:0042493 [response to drug] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043295 [glutathione binding] GO:0044281 [small molecule metabolic process] GO:0045177 [apical part of cell] GO:0055114 [oxidation-reduction process] GO:0070207 [protein homotrimerization] GO:0071449 [cellular response to lipid hydroperoxide] GO:1901687 [glutathione derivative biosynthetic process] Show all	155 aa 17.6 kDa	No	4