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MGST1
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

MGST1

Gene description

Microsomal glutathione S-transferase 1

Protein class

Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous cytoplasmic expression in a granular pattern.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
HPA044840
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin05001,0001,5002,000TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin020406080100120140RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina05001,0001,5002,0002,5003,0003,500Tags Per Million

GENE INFORMATION

Gene name

MGST1 (HGNC Symbol)

Synonyms

GST12, MGST-I

Description

Microsomal glutathione S-transferase 1 (HGNC Symbol)

Entrez gene summary

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]

Chromosome

12

Cytoband

p12.3

Chromosome location (bp)

16347142 - 16609259

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000008394 (version 83.38)

Entrez gene

4257

UniProt

P10620 (UniProt - Evidence at protein level)

neXtProt

NX_P10620

Antibodypedia

MGST1 antibodies

PROTEIN BROWSER

MGST1-001
MGST1-002
MGST1-004
MGST1-005
MGST1-006
MGST1-007
MGST1-009
MGST1-013
MGST1-201
MGST1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MGST1-001
ENSP00000379513
ENST00000396210
P10620 [Direct mapping]
Microsomal glutathione S-transferase 1
A0A024RAX2 [Target identity:100%; Query identity:100%]
Microsomal glutathione S-transferase 1, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004364 [glutathione transferase activity]
GO:0004602 [glutathione peroxidase activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005778 [peroxisomal membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006805 [xenobiotic metabolic process]
GO:0016021 [integral component of membrane]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070207 [protein homotrimerization]
GO:0071449 [cellular response to lipid hydroperoxide]
GO:1901687 [glutathione derivative biosynthetic process]
Show all
155 aa
17.6 kDa
No 4
MGST1-002
ENSP00000379510
ENST00000396207
P10620 [Direct mapping]
Microsomal glutathione S-transferase 1
A0A024RAX2 [Target identity:100%; Query identity:100%]
Microsomal glutathione S-transferase 1, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004364 [glutathione transferase activity]
GO:0004602 [glutathione peroxidase activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005778 [peroxisomal membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006805 [xenobiotic metabolic process]
GO:0016021 [integral component of membrane]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070207 [protein homotrimerization]
GO:0071449 [cellular response to lipid hydroperoxide]
GO:1901687 [glutathione derivative biosynthetic process]
Show all
155 aa
17.6 kDa
No 4
MGST1-004
ENSP00000438308
ENST00000535309
P10620 [Direct mapping]
Microsomal glutathione S-transferase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004364 [glutathione transferase activity]
GO:0004602 [glutathione peroxidase activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005778 [peroxisomal membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006805 [xenobiotic metabolic process]
GO:0016021 [integral component of membrane]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070207 [protein homotrimerization]
GO:0071449 [cellular response to lipid hydroperoxide]
GO:1901687 [glutathione derivative biosynthetic process]
Show all
87 aa
10 kDa
No 1
MGST1-005
ENSP00000442557
ENST00000536371
F5H7F6 [Direct mapping]
Microsomal glutathione S-transferase 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
77 aa
8.9 kDa
No 1
MGST1-006
ENSP00000442970
ENST00000540126
F5H6X2 [Direct mapping]
Microsomal glutathione S-transferase 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
80 aa
9.2 kDa
No 1
MGST1-007
ENSP00000437988
ENST00000540056
F5H613 [Direct mapping]
Microsomal glutathione S-transferase 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
46 aa
5.3 kDa
No 1
MGST1-009
ENSP00000440443
ENST00000538885
F5GX73 [Direct mapping]
Microsomal glutathione S-transferase 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
42 aa
4.8 kDa
No 1
MGST1-013
ENSP00000442767
ENST00000543076
F5H760 [Direct mapping]
Microsomal glutathione S-transferase 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
106 aa
11.9 kDa
No 0
MGST1-201
ENSP00000010404
ENST00000010404
P10620 [Direct mapping]
Microsomal glutathione S-transferase 1
A0A024RAX2 [Target identity:100%; Query identity:100%]
Microsomal glutathione S-transferase 1, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004364 [glutathione transferase activity]
GO:0004602 [glutathione peroxidase activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005778 [peroxisomal membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006805 [xenobiotic metabolic process]
GO:0016021 [integral component of membrane]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070207 [protein homotrimerization]
GO:0071449 [cellular response to lipid hydroperoxide]
GO:1901687 [glutathione derivative biosynthetic process]
Show all
155 aa
17.6 kDa
No 4
MGST1-202
ENSP00000379512
ENST00000396209
P10620 [Direct mapping]
Microsomal glutathione S-transferase 1
A0A024RAX2 [Target identity:100%; Query identity:100%]
Microsomal glutathione S-transferase 1, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004364 [glutathione transferase activity]
GO:0004602 [glutathione peroxidase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005743 [mitochondrial inner membrane]
GO:0005778 [peroxisomal membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006749 [glutathione metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0010243 [response to organonitrogen compound]
GO:0016021 [integral component of membrane]
GO:0032496 [response to lipopolysaccharide]
GO:0033327 [Leydig cell differentiation]
GO:0042493 [response to drug]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043295 [glutathione binding]
GO:0044281 [small molecule metabolic process]
GO:0045177 [apical part of cell]
GO:0055114 [oxidation-reduction process]
GO:0070207 [protein homotrimerization]
GO:0071449 [cellular response to lipid hydroperoxide]
GO:1901687 [glutathione derivative biosynthetic process]
Show all
155 aa
17.6 kDa
No 4

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The Human Protein Atlas project is funded
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