Expression of RHOBTB2 in cancer - Summary

CANCER ATLAS

Gene description

Rho-related BTB domain containing 2

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at transcript level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA060938

GENE INFORMATION
Gene name	RHOBTB2 (HGNC Symbol)
Synonyms	DBC2, KIAA0717
Description	Rho-related BTB domain containing 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Chromosome	8
Cytoband	p21.3
Chromosome location (bp)	22987417 - 23020199
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000008853 (version 83.38)
Entrez gene	23221
UniProt	Q9BYZ6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9BYZ6
Antibodypedia	RHOBTB2 antibodies

PROTEIN BROWSER

RHOBTB2-001	RHOBTB2-002	RHOBTB2-003	RHOBTB2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RHOBTB2-001 ENSP00000251822 ENST00000251822	Q9BYZ6 [Direct mapping] Rho-related BTB domain-containing protein 2 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	727 aa 82.6 kDa	No	0
RHOBTB2-002 ENSP00000427926 ENST00000519685	Q9BYZ6 [Direct mapping] Rho-related BTB domain-containing protein 2 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	749 aa 85.1 kDa	No	0
RHOBTB2-003 ENSP00000429141 ENST00000522948	Q9BYZ6 [Direct mapping] Rho-related BTB domain-containing protein 2 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	734 aa 83.5 kDa	No	0
RHOBTB2-004 ENSP00000430785 ENST00000524077	E5RI44 [Direct mapping] Rho-related BTB domain-containing protein 2 Show all	Predicted intracellular proteins Show all	GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] Show all	182 aa 20.8 kDa	No	0