Cell atlas - RHOBTB2 - The Human Protein Atlas

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RHOBTB2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Plasma membrane

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	RHOBTB2
Gene description	Rho-related BTB domain containing 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane.
RNA cell category	Expressed in all
Protein evidence	Evidence at transcript level
Main location	Localized to the Plasma membrane (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA060938
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane.

Main location

Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA060938	CACO-2	No staining
	HPA060938	RT4	Aggresome
	HPA060938	U-2 OS	Plasma membrane	Intensity

GENE INFORMATION
Gene name	RHOBTB2 (HGNC Symbol)
Synonyms	DBC2, KIAA0717
Description	Rho-related BTB domain containing 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Chromosome	8
Cytoband	p21.3
Chromosome location (bp)	22987417 - 23020199
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000008853 (version 83.38)
Entrez gene	23221
UniProt	Q9BYZ6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9BYZ6
Antibodypedia	RHOBTB2 antibodies

PROTEIN BROWSER

RHOBTB2-001	RHOBTB2-002	RHOBTB2-003	RHOBTB2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RHOBTB2-001 ENSP00000251822 ENST00000251822	Q9BYZ6 [Direct mapping] Rho-related BTB domain-containing protein 2 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	727 aa 82.6 kDa	No	0
RHOBTB2-002 ENSP00000427926 ENST00000519685	Q9BYZ6 [Direct mapping] Rho-related BTB domain-containing protein 2 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	749 aa 85.1 kDa	No	0
RHOBTB2-003 ENSP00000429141 ENST00000522948	Q9BYZ6 [Direct mapping] Rho-related BTB domain-containing protein 2 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	734 aa 83.5 kDa	No	0
RHOBTB2-004 ENSP00000430785 ENST00000524077	E5RI44 [Direct mapping] Rho-related BTB domain-containing protein 2 Show all	Predicted intracellular proteins Show all	GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] Show all	182 aa 20.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.