We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fragments of moderate luminal membranous positivity was observed in most colorectal cancers and rare cases of ovarian, cervical, endometrial, testis, urothelial, lung and pancreatic cancers. Remaining tissues were weakly stained or negative.
Moderate cytoplasmic positivity often with a granular pattern in a few cases of for example colorectal, testis, breast and prostate cancers. Most other cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
PHF7 (HGNC Symbol)
Synonyms
HSPC226, NYD-SP6
Description
PHD finger protein 7 (HGNC Symbol)
Entrez gene summary
Spermatogenesis is a complex process regulated by extracellular and intracellular factors as well as cellular interactions among interstitial cells of the testis, Sertoli cells, and germ cells. This gene is expressed in the testis in Sertoli cells but not germ cells. The protein encoded by this gene contains plant homeodomain (PHD) finger domains, also known as leukemia associated protein (LAP) domains, believed to be involved in transcriptional regulation. The protein, which localizes to the nucleus of transfected cells, has been implicated in the transcriptional regulation of spermatogenesis. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
