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NME1-NME2

CANCER ATLAS

Gene description

 NME1-NME2 readthrough

Protein class

 Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA008467
HPA041113
CAB002169

GENE INFORMATION

Gene name

 NME1-NME2 (HGNC Symbol)

Synonyms

 NM23-LV, NMELV

Description

 NME1-NME2 readthrough (HGNC Symbol)

Entrez gene summary

 This locus represents naturally occurring read-through transcription between the neighboring NME1 and NME2 genes. The significance of this read-through transcription and the function of the resulting protein product have not yet been determined. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2010]

Chromosome

 17

Cytoband

 q21.33

Chromosome location (bp)

 51153590 - 51171744

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000011052 (version 83.38)

Entrez gene

 654364

UniProt

 P22392 (UniProt - Evidence at protein level)

neXtProt

 NX_P22392

Antibodypedia

 NME1-NME2 antibodies

PROTEIN BROWSER
NME1-NME2-001
NME1-NME2-002
NME1-NME2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NME1-NME2-001
ENSP00000376889
ENST00000393193
P22392 [Direct mapping]
Nucleoside diphosphate kinase B
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0001726 [ruffle]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0004673 [protein histidine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006163 [purine nucleotide metabolic process]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006220 [pyrimidine nucleotide metabolic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007155 [cell adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0009142 [nucleoside triphosphate biosynthetic process]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0018106 [peptidyl-histidine phosphorylation]
GO:0030027 [lamellipodium]
GO:0043066 [negative regulation of apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0045618 [positive regulation of keratinocyte differentiation]
GO:0045682 [regulation of epidermis development]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 267 aa
30.1 kDa 		No 0
NME1-NME2-002
ENSP00000451932
ENST00000555572
Q32Q12 [Direct mapping]
Nucleoside diphosphate kinase
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0006163 [purine nucleotide metabolic process]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006220 [pyrimidine nucleotide metabolic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
Show all
 292 aa
32.6 kDa 		Yes 0
NME1-NME2-003
ENSP00000365572
ENST00000376392
J3KPD9 [Direct mapping]
Nucleoside diphosphate kinase B
Show all
Predicted intracellular proteins
Show all
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0006163 [purine nucleotide metabolic process]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006220 [pyrimidine nucleotide metabolic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
Show all
 197 aa
22.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.