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NME1-NME2

GENERAL INFORMATION

Gene name

 NME1-NME2

Gene description

 NME1-NME2 readthrough

Protein class

 Cancer-related genes
Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 3 antibodies.
HPA008467 , HPA041113 , CAB002169
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Urinary bladder

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 NME1-NME2 (HGNC Symbol)

Synonyms

 NM23-LV, NMELV

Description

 NME1-NME2 readthrough (HGNC Symbol)

Entrez gene summary

 This locus represents naturally occurring read-through transcription between the neighboring NME1 and NME2 genes. The significance of this read-through transcription and the function of the resulting protein product have not yet been determined. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2010]

Chromosome

 17

Cytoband

 q21.33

Chromosome location (bp)

 51153590 - 51171744

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000011052 (version 83.38)

Entrez gene

 654364

UniProt

 P22392 (UniProt - Evidence at protein level)

neXtProt

 NX_P22392

Antibodypedia

 NME1-NME2 antibodies

PROTEIN BROWSER
NME1-NME2-001
NME1-NME2-002
NME1-NME2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NME1-NME2-001
ENSP00000376889
ENST00000393193
P22392 [Direct mapping]
Nucleoside diphosphate kinase B
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0001726 [ruffle]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0004673 [protein histidine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006163 [purine nucleotide metabolic process]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006220 [pyrimidine nucleotide metabolic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007155 [cell adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0009142 [nucleoside triphosphate biosynthetic process]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0018106 [peptidyl-histidine phosphorylation]
GO:0030027 [lamellipodium]
GO:0043066 [negative regulation of apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0045618 [positive regulation of keratinocyte differentiation]
GO:0045682 [regulation of epidermis development]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
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 267 aa
30.1 kDa 		No 0
NME1-NME2-002
ENSP00000451932
ENST00000555572
Q32Q12 [Direct mapping]
Nucleoside diphosphate kinase
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
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GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0006163 [purine nucleotide metabolic process]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006220 [pyrimidine nucleotide metabolic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
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 292 aa
32.6 kDa 		Yes 0
NME1-NME2-003
ENSP00000365572
ENST00000376392
J3KPD9 [Direct mapping]
Nucleoside diphosphate kinase B
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Predicted intracellular proteins
Show all
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0006163 [purine nucleotide metabolic process]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006220 [pyrimidine nucleotide metabolic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
Show all
 197 aa
22.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.