Expression of ANLN in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Anillin actin binding protein

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA005680	HPA050556	CAB033902	CAB062547	CAB068175

GENE INFORMATION
Gene name	ANLN (HGNC Symbol)
Synonyms	ANILLIN, scra, Scraps
Description	Anillin actin binding protein (HGNC Symbol)
Entrez gene summary	This gene encodes an actin-binding protein that plays a role in cell growth and migration, and in cytokinesis. The encoded protein is thought to regulate actin cytoskeletal dynamics in podocytes, components of the glomerulus. Mutations in this gene are associated with focal segmental glomerulosclerosis 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Chromosome	7
Cytoband	p14.2
Chromosome location (bp)	36389806 - 36453791
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000011426 (version 83.38)
Entrez gene	54443
UniProt	Q9NQW6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NQW6
Antibodypedia	ANLN antibodies

PROTEIN BROWSER

ANLN-001	ANLN-002	ANLN-004	ANLN-005	ANLN-009	ANLN-012	ANLN-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANLN-001 ENSP00000265748 ENST00000265748	Q9NQW6 [Direct mapping] Actin-binding protein anillin A0A024RA49 [Target identity:100%; Query identity:100%] Anillin, actin binding protein (Scraps homolog, Drosophila), isoform CRA_e Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000281 [mitotic cytokinesis] GO:0000921 [septin ring assembly] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005826 [actomyosin contractile ring] GO:0007067 [mitotic nuclear division] GO:0007096 [regulation of exit from mitosis] GO:0015629 [actin cytoskeleton] GO:0043231 [intracellular membrane-bounded organelle] GO:0090521 [glomerular visceral epithelial cell migration] Show all	1124 aa 124.2 kDa	No	0
ANLN-002 ENSP00000379380 ENST00000396068	Q9NQW6 [Direct mapping] Actin-binding protein anillin Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000281 [mitotic cytokinesis] GO:0000921 [septin ring assembly] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005826 [actomyosin contractile ring] GO:0007067 [mitotic nuclear division] GO:0007096 [regulation of exit from mitosis] GO:0015629 [actin cytoskeleton] GO:0043231 [intracellular membrane-bounded organelle] GO:0090521 [glomerular visceral epithelial cell migration] Show all	1087 aa 120 kDa	No	0
ANLN-004 ENSP00000404979 ENST00000424865	C9JJT6 [Direct mapping] Actin-binding protein anillin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		169 aa 18.2 kDa	No	0
ANLN-005 ENSP00000406584 ENST00000418118	C9J0G4 [Direct mapping] Actin-binding protein anillin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		36 aa 3.8 kDa	No	0
ANLN-009 ENSP00000413522 ENST00000428612	H7C3S1 [Direct mapping] Actin-binding protein anillin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		236 aa 26.6 kDa	No	0
ANLN-012 ENSP00000400777 ENST00000446635	H7C1K5 [Direct mapping] Actin-binding protein anillin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		277 aa 30.8 kDa	No	0
ANLN-013 ENSP00000399553 ENST00000457743	H7C1C2 [Direct mapping] Actin-binding protein anillin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		252 aa 27.8 kDa	No	0