Cell atlas - ANLN - The Human Protein Atlas

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ANLN

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA CELL CYCLE MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ANLN
Gene description	Anillin actin binding protein
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by correlation analysis and custom assay
Mouse	Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA050556
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA050556	A-431	Nucleoplasm	Intensity
	HPA050556	U-2 OS	Nucleoplasm	Intensity	Intensity
	HPA050556	U-251 MG	Nucleoplasm	Intensity

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA050556	U-2 OS	Image	Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. ANLN is mostly expressed during S and/or G2.

CELL CYCLE
Summary	Expression has cell cycle dependency according to correlation analysis and custom assay
Intensity variation	Nucleoplasm
HPA050556

MOUSE CELLS

Main location

Nucleoplasm

Mouse gene

ENSMUSG00000036777 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA050556	NIH 3T3	Nucleoplasm

GENE INFORMATION
Gene name	ANLN (HGNC Symbol)
Synonyms	ANILLIN, scra, Scraps
Description	Anillin actin binding protein (HGNC Symbol)
Entrez gene summary	This gene encodes an actin-binding protein that plays a role in cell growth and migration, and in cytokinesis. The encoded protein is thought to regulate actin cytoskeletal dynamics in podocytes, components of the glomerulus. Mutations in this gene are associated with focal segmental glomerulosclerosis 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Chromosome	7
Cytoband	p14.2
Chromosome location (bp)	36389806 - 36453791
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000011426 (version 83.38)
Entrez gene	54443
UniProt	Q9NQW6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NQW6
Antibodypedia	ANLN antibodies

PROTEIN BROWSER

ANLN-001	ANLN-002	ANLN-004	ANLN-005	ANLN-009	ANLN-012	ANLN-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANLN-001 ENSP00000265748 ENST00000265748	Q9NQW6 [Direct mapping] Actin-binding protein anillin A0A024RA49 [Target identity:100%; Query identity:100%] Anillin, actin binding protein (Scraps homolog, Drosophila), isoform CRA_e Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000281 [mitotic cytokinesis] GO:0000921 [septin ring assembly] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005826 [actomyosin contractile ring] GO:0007067 [mitotic nuclear division] GO:0007096 [regulation of exit from mitosis] GO:0015629 [actin cytoskeleton] GO:0043231 [intracellular membrane-bounded organelle] GO:0090521 [glomerular visceral epithelial cell migration] Show all	1124 aa 124.2 kDa	No	0
ANLN-002 ENSP00000379380 ENST00000396068	Q9NQW6 [Direct mapping] Actin-binding protein anillin Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000281 [mitotic cytokinesis] GO:0000921 [septin ring assembly] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005826 [actomyosin contractile ring] GO:0007067 [mitotic nuclear division] GO:0007096 [regulation of exit from mitosis] GO:0015629 [actin cytoskeleton] GO:0043231 [intracellular membrane-bounded organelle] GO:0090521 [glomerular visceral epithelial cell migration] Show all	1087 aa 120 kDa	No	0
ANLN-004 ENSP00000404979 ENST00000424865	C9JJT6 [Direct mapping] Actin-binding protein anillin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		169 aa 18.2 kDa	No	0
ANLN-005 ENSP00000406584 ENST00000418118	C9J0G4 [Direct mapping] Actin-binding protein anillin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		36 aa 3.8 kDa	No	0
ANLN-009 ENSP00000413522 ENST00000428612	H7C3S1 [Direct mapping] Actin-binding protein anillin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		236 aa 26.6 kDa	No	0
ANLN-012 ENSP00000400777 ENST00000446635	H7C1K5 [Direct mapping] Actin-binding protein anillin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		277 aa 30.8 kDa	No	0
ANLN-013 ENSP00000399553 ENST00000457743	H7C1C2 [Direct mapping] Actin-binding protein anillin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		252 aa 27.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.