Expression of EXTL3 in cancer - Summary

CANCER ATLAS

Gene description

Exostosin-like glycosyltransferase 3

Protein class

Enzymes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Pancreatic cancer

STAINING SUMMARY

CAB025387

GENE INFORMATION
Gene name	EXTL3 (HGNC Symbol)
Synonyms	botv, REGR
Description	Exostosin-like glycosyltransferase 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a single-pass membrane protein which functions as a glycosyltransferase. The encoded protein catalyzes the transfer of N-acetylglucosamine to glycosaminoglycan chains. This reaction is important in heparin and heparan sulfate synthesis. Alternative splicing results in the multiple transcript variants. [provided by RefSeq, Nov 2012]
Chromosome	8
Cytoband	p21.1
Chromosome location (bp)	28600469 - 28755599
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000012232 (version 83.38)
Entrez gene	2137
UniProt	O43909 (UniProt - Evidence at protein level)
neXtProt	NX_O43909
Antibodypedia	EXTL3 antibodies

PROTEIN BROWSER

EXTL3-001	EXTL3-002	EXTL3-009	EXTL3-012	EXTL3-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EXTL3-001 ENSP00000220562 ENST00000220562	O43909 [Direct mapping] Exostosin-like 3 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001888 [glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity] GO:0004872 [receptor activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0015012 [heparan sulfate proteoglycan biosynthetic process] GO:0016021 [integral component of membrane] GO:0030307 [positive regulation of cell growth] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0036498 [IRE1-mediated unfolded protein response] GO:0044267 [cellular protein metabolic process] GO:0046872 [metal ion binding] Show all	919 aa 104.7 kDa	No	1
EXTL3-002 ENSP00000428691 ENST00000523149	E7ET85 [Direct mapping] Exostosin-like 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006024 [glycosaminoglycan biosynthetic process] GO:0015012 [heparan sulfate proteoglycan biosynthetic process] GO:0016021 [integral component of membrane] Show all	535 aa 61.1 kDa	No	0
EXTL3-009 ENSP00000431013 ENST00000521532	E5RK02 [Direct mapping] Exostosin-like 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006024 [glycosaminoglycan biosynthetic process] GO:0015012 [heparan sulfate proteoglycan biosynthetic process] GO:0016021 [integral component of membrane] Show all	138 aa 16.5 kDa	No	0
EXTL3-012 ENSP00000430652 ENST00000517738	E5RIV6 [Direct mapping] Exostosin-like 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006024 [glycosaminoglycan biosynthetic process] GO:0015012 [heparan sulfate proteoglycan biosynthetic process] GO:0016021 [integral component of membrane] Show all	118 aa 14 kDa	No	0
EXTL3-014 ENSP00000429627 ENST00000521473	H0YBJ7 [Direct mapping] Exostosin-like 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006024 [glycosaminoglycan biosynthetic process] GO:0015012 [heparan sulfate proteoglycan biosynthetic process] GO:0016021 [integral component of membrane] Show all	201 aa 23.7 kDa	No	0