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EXTL3

GENERAL INFORMATION

Gene name

 EXTL3

Gene description

 Exostosin-like glycosyltransferase 3

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
CAB025387
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 EXTL3 (HGNC Symbol)

Synonyms

 botv, REGR

Description

 Exostosin-like glycosyltransferase 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a single-pass membrane protein which functions as a glycosyltransferase. The encoded protein catalyzes the transfer of N-acetylglucosamine to glycosaminoglycan chains. This reaction is important in heparin and heparan sulfate synthesis. Alternative splicing results in the multiple transcript variants. [provided by RefSeq, Nov 2012]

Chromosome

 8

Cytoband

 p21.1

Chromosome location (bp)

 28600469 - 28755599

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000012232 (version 83.38)

Entrez gene

 2137

UniProt

 O43909 (UniProt - Evidence at protein level)

neXtProt

 NX_O43909

Antibodypedia

 EXTL3 antibodies

PROTEIN BROWSER
EXTL3-001
EXTL3-002
EXTL3-009
EXTL3-012
EXTL3-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EXTL3-001
ENSP00000220562
ENST00000220562
O43909 [Direct mapping]
Exostosin-like 3
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Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001888 [glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity]
GO:0004872 [receptor activity]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006024 [glycosaminoglycan biosynthetic process]
GO:0015012 [heparan sulfate proteoglycan biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0030307 [positive regulation of cell growth]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0044267 [cellular protein metabolic process]
GO:0046872 [metal ion binding]
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 919 aa
104.7 kDa 		No 1
EXTL3-002
ENSP00000428691
ENST00000523149
E7ET85 [Direct mapping]
Exostosin-like 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006024 [glycosaminoglycan biosynthetic process]
GO:0015012 [heparan sulfate proteoglycan biosynthetic process]
GO:0016021 [integral component of membrane]
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 535 aa
61.1 kDa 		No 0
EXTL3-009
ENSP00000431013
ENST00000521532
E5RK02 [Direct mapping]
Exostosin-like 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006024 [glycosaminoglycan biosynthetic process]
GO:0015012 [heparan sulfate proteoglycan biosynthetic process]
GO:0016021 [integral component of membrane]
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 138 aa
16.5 kDa 		No 0
EXTL3-012
ENSP00000430652
ENST00000517738
E5RIV6 [Direct mapping]
Exostosin-like 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006024 [glycosaminoglycan biosynthetic process]
GO:0015012 [heparan sulfate proteoglycan biosynthetic process]
GO:0016021 [integral component of membrane]
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 118 aa
14 kDa 		No 0
EXTL3-014
ENSP00000429627
ENST00000521473
H0YBJ7 [Direct mapping]
Exostosin-like 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006024 [glycosaminoglycan biosynthetic process]
GO:0015012 [heparan sulfate proteoglycan biosynthetic process]
GO:0016021 [integral component of membrane]
Show all
 201 aa
23.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.