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WWTR1

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GENERAL INFORMATION

Gene name

 WWTR1

Gene description

 WW domain containing transcription regulator 1

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nuclear bodies & nucleoplasm. In addition localized to the cytosol.

RNA cell category

 Cell line enhanced (EFO-21)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated), Nuclear bodies (supported)

Additional location

 In addition localized to the Cytosol (validated)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA007415 , CAB017483
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (EFO-21)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nuclear bodies & nucleoplasm. In addition localized to the cytosol.

Main location

 Nucleoplasm (validated), Nuclear bodies (supported)

Additional location

 Cytosol (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB017483 A-431 Nucleoplasm
CAB017483 U-2 OS Nucleoplasm
CAB017483 U-251 MG Nucleoplasm
Cytosol
HPA007415 A-431 Nucleoplasm
Nuclear bodies
Cytosol
HPA007415 U-2 OS Nucleoplasm
Nuclear bodies
Cytosol
HPA007415 U-251 MG Nucleoplasm
Nuclear bodies
Cytosol

GENE INFORMATION

Gene name

 WWTR1 (HGNC Symbol)

Synonyms

 DKFZp586I1419, TAZ

Description

 WW domain containing transcription regulator 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 3

Cytoband

 q25.1

Chromosome location (bp)

 149517235 - 149736714

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000018408 (version 83.38)

Entrez gene

 25937

UniProt

 Q9GZV5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9GZV5

Antibodypedia

 WWTR1 antibodies

PROTEIN BROWSER
WWTR1-001
WWTR1-003
WWTR1-004
WWTR1-006
WWTR1-007
WWTR1-008
WWTR1-009
WWTR1-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
WWTR1-001
ENSP00000419465
ENST00000465804
Q9GZV5 [Direct mapping]
WW domain-containing transcription regulator protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001649 [osteoblast differentiation]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0010467 [gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0016567 [protein ubiquitination]
GO:0017145 [stem cell division]
GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0032835 [glomerulus development]
GO:0035264 [multicellular organism growth]
GO:0035329 [hippo signaling]
GO:0035414 [negative regulation of catenin import into nucleus]
GO:0042803 [protein homodimerization activity]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048762 [mesenchymal cell differentiation]
GO:0060271 [cilium morphogenesis]
GO:0060390 [regulation of SMAD protein import into nucleus]
GO:0060828 [regulation of canonical Wnt signaling pathway]
GO:0060993 [kidney morphogenesis]
GO:0072307 [regulation of metanephric nephron tubule epithelial cell differentiation]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
Show all
 400 aa
44.1 kDa 		No 0
WWTR1-003
ENSP00000419234
ENST00000467467
Q9GZV5 [Direct mapping]
WW domain-containing transcription regulator protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001933 [negative regulation of protein phosphorylation]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0010467 [gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0017145 [stem cell division]
GO:0035329 [hippo signaling]
GO:0035414 [negative regulation of catenin import into nucleus]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060390 [regulation of SMAD protein import into nucleus]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
Show all
 400 aa
44.1 kDa 		No 0
WWTR1-004
ENSP00000353847
ENST00000360632
Q9GZV5 [Direct mapping]
WW domain-containing transcription regulator protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001933 [negative regulation of protein phosphorylation]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0010467 [gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0017145 [stem cell division]
GO:0035329 [hippo signaling]
GO:0035414 [negative regulation of catenin import into nucleus]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060390 [regulation of SMAD protein import into nucleus]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
Show all
 400 aa
44.1 kDa 		No 0
WWTR1-006
ENSP00000420159
ENST00000475579
C9JQS8 [Direct mapping]
WW domain-containing transcription regulator protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 109 aa
11.3 kDa 		No 0
WWTR1-007
ENSP00000417984
ENST00000460517
C9J588 [Direct mapping]
WW domain-containing transcription regulator protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 21 aa
2.1 kDa 		No 0
WWTR1-008
ENSP00000420120
ENST00000485352
C9JR84 [Direct mapping]
WW domain-containing transcription regulator protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 138 aa
14.6 kDa 		No 0
WWTR1-009
ENSP00000418580
ENST00000479238
C9J038 [Direct mapping]
WW domain-containing transcription regulator protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
Show all
 189 aa
20.5 kDa 		No 0
WWTR1-010
ENSP00000417339
ENST00000472417
C9J337 [Direct mapping]
WW domain-containing transcription regulator protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 247 aa
27.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.