We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
HGF
  • TISSUE

  • CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

Hepatocyte growth factor (hepapoietin A; scatter factor)

Protein class

Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins, RAS pathway related proteins

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA040360
HPA044088
CAB010333

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancers displayed weak to moderate cytoplasmic staining with additional membranous positivity in some cases. Occasional cases of carcinoid, breast, colorectal, prostate and endometrial cancers showed strong immunoreactivity. Many cases of squamous and basal cell carcinomas along with lymphomas and melanomas were negative.

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues displayed moderate to strong cytoplasmic staining. Several cases of skin, testicular and cervical cancers were weakly stained or negative.

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancers displayed weak to moderate cytoplasmic immunoreactivity. Several cases of skin cancers were mainly negative.

GENE INFORMATION

Gene name

HGF (HGNC Symbol)

Synonyms

DFNB39, F-TCF, HGFB, HPTA, SF

Description

Hepatocyte growth factor (hepapoietin A; scatter factor) (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]

Chromosome

7

Cytoband

q21.11

Chromosome location (bp)

81699006 - 81770438

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000019991 (version 83.38)

Entrez gene

3082

UniProt

P14210 (UniProt - Evidence at protein level)

neXtProt

NX_P14210

Antibodypedia

HGF antibodies

PROTEIN BROWSER

HGF-001
HGF-002
HGF-003
HGF-004
HGF-005
HGF-006
HGF-007
HGF-008
HGF-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HGF-001
ENSP00000222390
ENST00000222390
P14210 [Direct mapping]
Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain
Show all
Enzymes
   Peptidases
   Serine-type peptidases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0000902 [cell morphogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001889 [liver development]
GO:0002576 [platelet degranulation]
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006508 [proteolysis]
GO:0007067 [mitotic nuclear division]
GO:0007596 [blood coagulation]
GO:0008083 [growth factor activity]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0010507 [negative regulation of autophagy]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0030212 [hyaluronan metabolic process]
GO:0030335 [positive regulation of cell migration]
GO:0031093 [platelet alpha granule lumen]
GO:0031100 [organ regeneration]
GO:0031643 [positive regulation of myelination]
GO:0035729 [cellular response to hepatocyte growth factor stimulus]
GO:0042056 [chemoattractant activity]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045766 [positive regulation of angiogenesis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050918 [positive chemotaxis]
GO:0051450 [myoblast proliferation]
GO:0060326 [cell chemotaxis]
GO:0060665 [regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling]
GO:0070572 [positive regulation of neuron projection regeneration]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:1900744 [regulation of p38MAPK cascade]
GO:1901299 [negative regulation of hydrogen peroxide-mediated programmed cell death]
GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:2000573 [positive regulation of DNA biosynthetic process]
Show all
728 aa
83.1 kDa
Yes 0
HGF-002
ENSP00000408270
ENST00000453411
P14210 [Direct mapping]
Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain
Show all
Enzymes
   Peptidases
   Serine-type peptidases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001837 [epithelial to mesenchymal transition]
GO:0002576 [platelet degranulation]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007067 [mitotic nuclear division]
GO:0007596 [blood coagulation]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0010507 [negative regulation of autophagy]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0030335 [positive regulation of cell migration]
GO:0031093 [platelet alpha granule lumen]
GO:0035729 [cellular response to hepatocyte growth factor stimulus]
GO:0042056 [chemoattractant activity]
GO:0042802 [identical protein binding]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050918 [positive chemotaxis]
GO:0060326 [cell chemotaxis]
GO:0060665 [regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:1901299 [negative regulation of hydrogen peroxide-mediated programmed cell death]
GO:2000573 [positive regulation of DNA biosynthetic process]
Show all
285 aa
33.2 kDa
Yes 0
HGF-003
ENSP00000389854
ENST00000444829
P14210 [Direct mapping]
Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain
Show all
Enzymes
   Peptidases
   Serine-type peptidases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001837 [epithelial to mesenchymal transition]
GO:0002576 [platelet degranulation]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007067 [mitotic nuclear division]
GO:0007596 [blood coagulation]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0010507 [negative regulation of autophagy]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0030335 [positive regulation of cell migration]
GO:0031093 [platelet alpha granule lumen]
GO:0035729 [cellular response to hepatocyte growth factor stimulus]
GO:0042056 [chemoattractant activity]
GO:0042802 [identical protein binding]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050918 [positive chemotaxis]
GO:0060326 [cell chemotaxis]
GO:0060665 [regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:1901299 [negative regulation of hydrogen peroxide-mediated programmed cell death]
GO:2000573 [positive regulation of DNA biosynthetic process]
Show all
290 aa
33.8 kDa
Yes 0
HGF-004
ENSP00000413829
ENST00000423064
P14210 [Direct mapping]
Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain
Show all
Enzymes
   Peptidases
   Serine-type peptidases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001837 [epithelial to mesenchymal transition]
GO:0002576 [platelet degranulation]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007067 [mitotic nuclear division]
GO:0007596 [blood coagulation]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0010507 [negative regulation of autophagy]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0030335 [positive regulation of cell migration]
GO:0031093 [platelet alpha granule lumen]
GO:0035729 [cellular response to hepatocyte growth factor stimulus]
GO:0042056 [chemoattractant activity]
GO:0042802 [identical protein binding]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050918 [positive chemotaxis]
GO:0060326 [cell chemotaxis]
GO:0060665 [regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:1901299 [negative regulation of hydrogen peroxide-mediated programmed cell death]
GO:2000573 [positive regulation of DNA biosynthetic process]
Show all
210 aa
24.1 kDa
Yes 0
HGF-005
ENSP00000391238
ENST00000457544
P14210 [Direct mapping]
Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain
Show all
Enzymes
   Peptidases
   Serine-type peptidases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001837 [epithelial to mesenchymal transition]
GO:0002576 [platelet degranulation]
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006508 [proteolysis]
GO:0007067 [mitotic nuclear division]
GO:0007596 [blood coagulation]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0010507 [negative regulation of autophagy]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0030335 [positive regulation of cell migration]
GO:0031093 [platelet alpha granule lumen]
GO:0035729 [cellular response to hepatocyte growth factor stimulus]
GO:0042056 [chemoattractant activity]
GO:0042802 [identical protein binding]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050918 [positive chemotaxis]
GO:0060326 [cell chemotaxis]
GO:0060665 [regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:1901299 [negative regulation of hydrogen peroxide-mediated programmed cell death]
GO:2000573 [positive regulation of DNA biosynthetic process]
Show all
723 aa
82.6 kDa
Yes 0
HGF-006
ENSP00000395468
ENST00000453018
C9JJ35 [Direct mapping]
Hepatocyte growth factor
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
58 aa
6.7 kDa
No 0
HGF-007
ENSP00000388592
ENST00000421558
C9JS80 [Direct mapping]
Hepatocyte growth factor
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
118 aa
13.6 kDa
Yes 0
HGF-008
ENSP00000396307
ENST00000412881
C9JDP4 [Direct mapping]
Hepatocyte growth factor
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
141 aa
16.2 kDa
Yes 0
HGF-201
ENSP00000346164
ENST00000354224
C9WSJ3 [Direct mapping]
Hepatocyte growth factor; Hepatocyte growth factor isoform 6
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
184 aa
21 kDa
Yes 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.