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Gene name

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Chromosome

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Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

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Searches

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Cell type

Expression

Tissue

Specificity

Cell line

Specificity

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Detectable

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Antibodies

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HGF
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

HGF

Gene description

Hepatocyte growth factor (hepapoietin A; scatter factor)

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (placenta)
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression and extracellular staining at variable levels in most tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.

Reliability score

Approved based on 3 antibodies.
HPA040360 , HPA044088 , CAB010333
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

HGF (HGNC Symbol)

Synonyms

DFNB39, F-TCF, HGFB, HPTA, SF

Description

Hepatocyte growth factor (hepapoietin A; scatter factor) (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]

Chromosome

7

Cytoband

q21.11

Chromosome location (bp)

81699006 - 81770438

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000019991 (version 83.38)

Entrez gene

3082

UniProt

P14210 (UniProt - Evidence at protein level)

neXtProt

NX_P14210

Antibodypedia

HGF antibodies

PROTEIN BROWSER

HGF-001
HGF-002
HGF-003
HGF-004
HGF-005
HGF-006
HGF-007
HGF-008
HGF-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HGF-001
ENSP00000222390
ENST00000222390
P14210 [Direct mapping]
Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain
Show all
Enzymes
   Peptidases
   Serine-type peptidases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0000902 [cell morphogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001889 [liver development]
GO:0002576 [platelet degranulation]
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006508 [proteolysis]
GO:0007067 [mitotic nuclear division]
GO:0007596 [blood coagulation]
GO:0008083 [growth factor activity]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0010507 [negative regulation of autophagy]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0030212 [hyaluronan metabolic process]
GO:0030335 [positive regulation of cell migration]
GO:0031093 [platelet alpha granule lumen]
GO:0031100 [organ regeneration]
GO:0031643 [positive regulation of myelination]
GO:0035729 [cellular response to hepatocyte growth factor stimulus]
GO:0042056 [chemoattractant activity]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045766 [positive regulation of angiogenesis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050918 [positive chemotaxis]
GO:0051450 [myoblast proliferation]
GO:0060326 [cell chemotaxis]
GO:0060665 [regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling]
GO:0070572 [positive regulation of neuron projection regeneration]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:1900744 [regulation of p38MAPK cascade]
GO:1901299 [negative regulation of hydrogen peroxide-mediated programmed cell death]
GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:2000573 [positive regulation of DNA biosynthetic process]
Show all
728 aa
83.1 kDa
Yes 0
HGF-002
ENSP00000408270
ENST00000453411
P14210 [Direct mapping]
Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain
Show all
Enzymes
   Peptidases
   Serine-type peptidases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001837 [epithelial to mesenchymal transition]
GO:0002576 [platelet degranulation]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007067 [mitotic nuclear division]
GO:0007596 [blood coagulation]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0010507 [negative regulation of autophagy]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0030335 [positive regulation of cell migration]
GO:0031093 [platelet alpha granule lumen]
GO:0035729 [cellular response to hepatocyte growth factor stimulus]
GO:0042056 [chemoattractant activity]
GO:0042802 [identical protein binding]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050918 [positive chemotaxis]
GO:0060326 [cell chemotaxis]
GO:0060665 [regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:1901299 [negative regulation of hydrogen peroxide-mediated programmed cell death]
GO:2000573 [positive regulation of DNA biosynthetic process]
Show all
285 aa
33.2 kDa
Yes 0
HGF-003
ENSP00000389854
ENST00000444829
P14210 [Direct mapping]
Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain
Show all
Enzymes
   Peptidases
   Serine-type peptidases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001837 [epithelial to mesenchymal transition]
GO:0002576 [platelet degranulation]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007067 [mitotic nuclear division]
GO:0007596 [blood coagulation]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0010507 [negative regulation of autophagy]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0030335 [positive regulation of cell migration]
GO:0031093 [platelet alpha granule lumen]
GO:0035729 [cellular response to hepatocyte growth factor stimulus]
GO:0042056 [chemoattractant activity]
GO:0042802 [identical protein binding]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050918 [positive chemotaxis]
GO:0060326 [cell chemotaxis]
GO:0060665 [regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:1901299 [negative regulation of hydrogen peroxide-mediated programmed cell death]
GO:2000573 [positive regulation of DNA biosynthetic process]
Show all
290 aa
33.8 kDa
Yes 0
HGF-004
ENSP00000413829
ENST00000423064
P14210 [Direct mapping]
Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain
Show all
Enzymes
   Peptidases
   Serine-type peptidases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001837 [epithelial to mesenchymal transition]
GO:0002576 [platelet degranulation]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007067 [mitotic nuclear division]
GO:0007596 [blood coagulation]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0010507 [negative regulation of autophagy]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0030335 [positive regulation of cell migration]
GO:0031093 [platelet alpha granule lumen]
GO:0035729 [cellular response to hepatocyte growth factor stimulus]
GO:0042056 [chemoattractant activity]
GO:0042802 [identical protein binding]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050918 [positive chemotaxis]
GO:0060326 [cell chemotaxis]
GO:0060665 [regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:1901299 [negative regulation of hydrogen peroxide-mediated programmed cell death]
GO:2000573 [positive regulation of DNA biosynthetic process]
Show all
210 aa
24.1 kDa
Yes 0
HGF-005
ENSP00000391238
ENST00000457544
P14210 [Direct mapping]
Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain
Show all
Enzymes
   Peptidases
   Serine-type peptidases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001837 [epithelial to mesenchymal transition]
GO:0002576 [platelet degranulation]
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006508 [proteolysis]
GO:0007067 [mitotic nuclear division]
GO:0007596 [blood coagulation]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0010507 [negative regulation of autophagy]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0030335 [positive regulation of cell migration]
GO:0031093 [platelet alpha granule lumen]
GO:0035729 [cellular response to hepatocyte growth factor stimulus]
GO:0042056 [chemoattractant activity]
GO:0042802 [identical protein binding]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050918 [positive chemotaxis]
GO:0060326 [cell chemotaxis]
GO:0060665 [regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:1901299 [negative regulation of hydrogen peroxide-mediated programmed cell death]
GO:2000573 [positive regulation of DNA biosynthetic process]
Show all
723 aa
82.6 kDa
Yes 0
HGF-006
ENSP00000395468
ENST00000453018
C9JJ35 [Direct mapping]
Hepatocyte growth factor
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
58 aa
6.7 kDa
No 0
HGF-007
ENSP00000388592
ENST00000421558
C9JS80 [Direct mapping]
Hepatocyte growth factor
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
118 aa
13.6 kDa
Yes 0
HGF-008
ENSP00000396307
ENST00000412881
C9JDP4 [Direct mapping]
Hepatocyte growth factor
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
141 aa
16.2 kDa
Yes 0
HGF-201
ENSP00000346164
ENST00000354224
C9WSJ3 [Direct mapping]
Hepatocyte growth factor; Hepatocyte growth factor isoform 6
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
184 aa
21 kDa
Yes 0

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