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RNH1

CANCER ATLAS

Gene description

 Ribonuclease/angiogenin inhibitor 1

Protein class

 Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA039223
HPA040781

GENE INFORMATION

Gene name

 RNH1 (HGNC Symbol)

Synonyms

 RAI, RNH

Description

 Ribonuclease/angiogenin inhibitor 1 (HGNC Symbol)

Entrez gene summary

 Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]

Chromosome

 11

Cytoband

 p15.5

Chromosome location (bp)

 494512 - 507300

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000023191 (version 83.38)

Entrez gene

 6050

UniProt

 P13489 (UniProt - Evidence at protein level)

neXtProt

 NX_P13489

Antibodypedia

 RNH1 antibodies

PROTEIN BROWSER
«
RNH1-001
RNH1-003
RNH1-004
RNH1-005
RNH1-009
RNH1-011
RNH1-012
RNH1-015
RNH1-016
RNH1-017
RNH1-019
RNH1-020
RNH1-024
RNH1-025
RNH1-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RNH1-001
ENSP00000348515
ENST00000356187
P13489 [Direct mapping]
Ribonuclease inhibitor
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006402 [mRNA catabolic process]
GO:0008428 [ribonuclease inhibitor activity]
GO:0032311 [angiogenin-PRI complex]
GO:0043086 [negative regulation of catalytic activity]
GO:0045765 [regulation of angiogenesis]
GO:0070062 [extracellular exosome]
Show all
 461 aa
50 kDa 		No 0
RNH1-003
ENSP00000380729
ENST00000397604
P13489 [Direct mapping]
Ribonuclease inhibitor
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006402 [mRNA catabolic process]
GO:0008428 [ribonuclease inhibitor activity]
GO:0032311 [angiogenin-PRI complex]
GO:0043086 [negative regulation of catalytic activity]
GO:0045765 [regulation of angiogenesis]
GO:0070062 [extracellular exosome]
Show all
 461 aa
50 kDa 		No 0
RNH1-004
ENSP00000346402
ENST00000354420
P13489 [Direct mapping]
Ribonuclease inhibitor
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006402 [mRNA catabolic process]
GO:0008428 [ribonuclease inhibitor activity]
GO:0032311 [angiogenin-PRI complex]
GO:0043086 [negative regulation of catalytic activity]
GO:0045765 [regulation of angiogenesis]
GO:0070062 [extracellular exosome]
Show all
 461 aa
50 kDa 		No 0
RNH1-005
ENSP00000435594
ENST00000533410
P13489 [Direct mapping]
Ribonuclease inhibitor
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006402 [mRNA catabolic process]
GO:0008428 [ribonuclease inhibitor activity]
GO:0032311 [angiogenin-PRI complex]
GO:0043086 [negative regulation of catalytic activity]
GO:0045765 [regulation of angiogenesis]
GO:0070062 [extracellular exosome]
Show all
 461 aa
50 kDa 		No 0
RNH1-009
ENSP00000433999
ENST00000534797
P13489 [Direct mapping]
Ribonuclease inhibitor
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006402 [mRNA catabolic process]
GO:0008428 [ribonuclease inhibitor activity]
GO:0032311 [angiogenin-PRI complex]
GO:0043086 [negative regulation of catalytic activity]
GO:0045765 [regulation of angiogenesis]
GO:0070062 [extracellular exosome]
Show all
 461 aa
50 kDa 		No 0
RNH1-011
ENSP00000380739
ENST00000397615
P13489 [Direct mapping]
Ribonuclease inhibitor
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006402 [mRNA catabolic process]
GO:0008428 [ribonuclease inhibitor activity]
GO:0032311 [angiogenin-PRI complex]
GO:0043086 [negative regulation of catalytic activity]
GO:0045765 [regulation of angiogenesis]
GO:0070062 [extracellular exosome]
Show all
 461 aa
50 kDa 		No 0
RNH1-012
ENSP00000416589
ENST00000438658
P13489 [Direct mapping]
Ribonuclease inhibitor
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006402 [mRNA catabolic process]
GO:0008428 [ribonuclease inhibitor activity]
GO:0032311 [angiogenin-PRI complex]
GO:0043086 [negative regulation of catalytic activity]
GO:0045765 [regulation of angiogenesis]
GO:0070062 [extracellular exosome]
Show all
 461 aa
50 kDa 		No 0
RNH1-015
ENSP00000435798
ENST00000531149
E9PIK5 [Direct mapping]
Ribonuclease inhibitor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
Show all
 181 aa
19.2 kDa 		No 0
RNH1-016
ENSP00000435057
ENST00000529368
E9PLZ3 [Direct mapping]
Ribonuclease inhibitor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
Show all
 194 aa
21 kDa 		No 0
RNH1-017
ENSP00000434947
ENST00000529306
E9PMJ3 [Direct mapping]
Ribonuclease inhibitor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
Show all
 189 aa
20.5 kDa 		No 0
RNH1-019
ENSP00000432781
ENST00000531540
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 8 aa
0.9 kDa 		No 0
RNH1-020
ENSP00000434971
ENST00000532055
E9PMI1 [Direct mapping]
Ribonuclease inhibitor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 40 aa
4.6 kDa 		No 0
RNH1-024
ENSP00000432170
ENST00000529768
H0YCR7 [Direct mapping]
Ribonuclease inhibitor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
Show all
 285 aa
30.4 kDa 		No 0
RNH1-025
ENSP00000435748
ENST00000527485
E9PIM9 [Direct mapping]
Ribonuclease inhibitor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
Show all
 199 aa
21.5 kDa 		No 0
RNH1-201
ENSP00000380738
ENST00000397614
P13489 [Direct mapping]
Ribonuclease inhibitor
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006402 [mRNA catabolic process]
GO:0008428 [ribonuclease inhibitor activity]
GO:0032311 [angiogenin-PRI complex]
GO:0043086 [negative regulation of catalytic activity]
GO:0045765 [regulation of angiogenesis]
GO:0070062 [extracellular exosome]
Show all
 461 aa
50 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.