Cell atlas - RNH1 - The Human Protein Atlas

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RNH1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	RNH1
Gene description	Ribonuclease/angiogenin inhibitor 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	15
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported), Cytosol (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA039223 , HPA040781
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & nucleoplasm.

Main location

Nucleoplasm (supported), Cytosol (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA039223	A-431	Nucleoplasm
HPA039223	A-431	Cytosol
HPA039223	U-2 OS	Nucleoplasm
HPA039223	U-2 OS	Cytosol
HPA040781	A-431	Nucleoplasm
HPA040781	A-431	Cytosol
HPA040781	U-2 OS	Nucleoplasm
HPA040781	U-2 OS	Cytosol
HPA040781	U-251 MG	Nucleoplasm
HPA040781	U-251 MG	Cytosol

GENE INFORMATION
Gene name	RNH1 (HGNC Symbol)
Synonyms	RAI, RNH
Description	Ribonuclease/angiogenin inhibitor 1 (HGNC Symbol)
Entrez gene summary	Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]
Chromosome	11
Cytoband	p15.5
Chromosome location (bp)	494512 - 507300
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000023191 (version 83.38)
Entrez gene	6050
UniProt	P13489 (UniProt - Evidence at protein level)
neXtProt	NX_P13489
Antibodypedia	RNH1 antibodies

PROTEIN BROWSER

RNH1-001	RNH1-003	RNH1-004	RNH1-005	RNH1-009	RNH1-011	RNH1-012	RNH1-015	RNH1-016	RNH1-017	RNH1-019	RNH1-020	RNH1-024	RNH1-025	RNH1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RNH1-001 ENSP00000348515 ENST00000356187	P13489 [Direct mapping] Ribonuclease inhibitor Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006402 [mRNA catabolic process] GO:0008428 [ribonuclease inhibitor activity] GO:0032311 [angiogenin-PRI complex] GO:0043086 [negative regulation of catalytic activity] GO:0045765 [regulation of angiogenesis] GO:0070062 [extracellular exosome] Show all	461 aa 50 kDa	No	0
RNH1-003 ENSP00000380729 ENST00000397604	P13489 [Direct mapping] Ribonuclease inhibitor Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006402 [mRNA catabolic process] GO:0008428 [ribonuclease inhibitor activity] GO:0032311 [angiogenin-PRI complex] GO:0043086 [negative regulation of catalytic activity] GO:0045765 [regulation of angiogenesis] GO:0070062 [extracellular exosome] Show all	461 aa 50 kDa	No	0
RNH1-004 ENSP00000346402 ENST00000354420	P13489 [Direct mapping] Ribonuclease inhibitor Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006402 [mRNA catabolic process] GO:0008428 [ribonuclease inhibitor activity] GO:0032311 [angiogenin-PRI complex] GO:0043086 [negative regulation of catalytic activity] GO:0045765 [regulation of angiogenesis] GO:0070062 [extracellular exosome] Show all	461 aa 50 kDa	No	0
RNH1-005 ENSP00000435594 ENST00000533410	P13489 [Direct mapping] Ribonuclease inhibitor Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006402 [mRNA catabolic process] GO:0008428 [ribonuclease inhibitor activity] GO:0032311 [angiogenin-PRI complex] GO:0043086 [negative regulation of catalytic activity] GO:0045765 [regulation of angiogenesis] GO:0070062 [extracellular exosome] Show all	461 aa 50 kDa	No	0
RNH1-009 ENSP00000433999 ENST00000534797	P13489 [Direct mapping] Ribonuclease inhibitor Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006402 [mRNA catabolic process] GO:0008428 [ribonuclease inhibitor activity] GO:0032311 [angiogenin-PRI complex] GO:0043086 [negative regulation of catalytic activity] GO:0045765 [regulation of angiogenesis] GO:0070062 [extracellular exosome] Show all	461 aa 50 kDa	No	0
RNH1-011 ENSP00000380739 ENST00000397615	P13489 [Direct mapping] Ribonuclease inhibitor Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006402 [mRNA catabolic process] GO:0008428 [ribonuclease inhibitor activity] GO:0032311 [angiogenin-PRI complex] GO:0043086 [negative regulation of catalytic activity] GO:0045765 [regulation of angiogenesis] GO:0070062 [extracellular exosome] Show all	461 aa 50 kDa	No	0
RNH1-012 ENSP00000416589 ENST00000438658	P13489 [Direct mapping] Ribonuclease inhibitor Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006402 [mRNA catabolic process] GO:0008428 [ribonuclease inhibitor activity] GO:0032311 [angiogenin-PRI complex] GO:0043086 [negative regulation of catalytic activity] GO:0045765 [regulation of angiogenesis] GO:0070062 [extracellular exosome] Show all	461 aa 50 kDa	No	0
RNH1-015 ENSP00000435798 ENST00000531149	E9PIK5 [Direct mapping] Ribonuclease inhibitor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	181 aa 19.2 kDa	No	0
RNH1-016 ENSP00000435057 ENST00000529368	E9PLZ3 [Direct mapping] Ribonuclease inhibitor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	194 aa 21 kDa	No	0
RNH1-017 ENSP00000434947 ENST00000529306	E9PMJ3 [Direct mapping] Ribonuclease inhibitor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	189 aa 20.5 kDa	No	0
RNH1-019 ENSP00000432781 ENST00000531540		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		8 aa 0.9 kDa	No	0
RNH1-020 ENSP00000434971 ENST00000532055	E9PMI1 [Direct mapping] Ribonuclease inhibitor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		40 aa 4.6 kDa	No	0
RNH1-024 ENSP00000432170 ENST00000529768	H0YCR7 [Direct mapping] Ribonuclease inhibitor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	285 aa 30.4 kDa	No	0
RNH1-025 ENSP00000435748 ENST00000527485	E9PIM9 [Direct mapping] Ribonuclease inhibitor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	199 aa 21.5 kDa	No	0
RNH1-201 ENSP00000380738 ENST00000397614	P13489 [Direct mapping] Ribonuclease inhibitor Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006402 [mRNA catabolic process] GO:0008428 [ribonuclease inhibitor activity] GO:0032311 [angiogenin-PRI complex] GO:0043086 [negative regulation of catalytic activity] GO:0045765 [regulation of angiogenesis] GO:0070062 [extracellular exosome] Show all	461 aa 50 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.