Cell atlas - STRAP - The Human Protein Atlas

GENERAL INFORMATION
Gene name	STRAP
Gene description	Serine/threonine kinase receptor associated protein
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (validated)
Additional location	In addition localized to the Nucleoplasm (supported)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA055557 , HPA073876
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the nucleoplasm.

Main location

Cytosol (validated)

Additional location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA055557	CACO-2	Nucleoplasm
HPA055557	CACO-2	Cytosol
HPA055557	U-2 OS	Cytosol
HPA073876	CACO-2	Cytosol
HPA073876	RH-30	Cytosol
HPA073876	U-2 OS	Cytosol

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000030224 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA055557	NIH 3T3	No staining

GENE INFORMATION
Gene name	STRAP (HGNC Symbol)
Synonyms	MAWD, pt-wd, UNRIP
Description	Serine/threonine kinase receptor associated protein (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	p12.3
Chromosome location (bp)	15882391 - 15903478
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000023734 (version 83.38)
Entrez gene	11171
UniProt	Q9Y3F4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y3F4
Antibodypedia	STRAP antibodies

PROTEIN BROWSER

STRAP-001	STRAP-002	STRAP-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STRAP-001 ENSP00000392270 ENST00000419869	Q9Y3F4 [Direct mapping] Serine-threonine kinase receptor-associated protein Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000387 [spliceosomal snRNP assembly] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0010633 [negative regulation of epithelial cell migration] GO:0010719 [negative regulation of epithelial to mesenchymal transition] GO:0030277 [maintenance of gastrointestinal epithelium] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0032797 [SMN complex] GO:0034719 [SMN-Sm protein complex] GO:0044822 [poly(A) RNA binding] GO:0050680 [negative regulation of epithelial cell proliferation] GO:0060394 [negative regulation of pathway-restricted SMAD protein phosphorylation] Show all	350 aa 38.4 kDa	No	0
STRAP-002 ENSP00000025399 ENST00000025399	Q9Y3F4 [Direct mapping] Serine-threonine kinase receptor-associated protein Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0000387 [spliceosomal snRNP assembly] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0010633 [negative regulation of epithelial cell migration] GO:0010719 [negative regulation of epithelial to mesenchymal transition] GO:0030277 [maintenance of gastrointestinal epithelium] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0032797 [SMN complex] GO:0034719 [SMN-Sm protein complex] GO:0044822 [poly(A) RNA binding] GO:0050680 [negative regulation of epithelial cell proliferation] GO:0060394 [negative regulation of pathway-restricted SMAD protein phosphorylation] Show all	363 aa 39.8 kDa	No	0
STRAP-006 ENSP00000445814 ENST00000538718	H0YH33 [Direct mapping] Serine-threonine kinase receptor-associated protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	95 aa 10.5 kDa	No	0