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EHD2

CANCER ATLAS

Gene description

 EH-domain containing 2

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA047394
HPA049890
HPA049986

GENE INFORMATION

Gene name

 EHD2 (HGNC Symbol)

Synonyms

 PAST2

Description

 EH-domain containing 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the EH domain-containing protein family. These proteins are characterized by a C-terminal EF-hand domain, a nucleotide-binding consensus site at the N terminus and a bipartite nuclear localization signal. The encoded protein interacts with the actin cytoskeleton through an N-terminal domain and also binds to an EH domain-binding protein through the C-terminal EH domain. This interaction appears to connect clathrin-dependent endocytosis to actin, suggesting that this gene product participates in the endocytic pathway. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.33

Chromosome location (bp)

 47713343 - 47743134

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000024422 (version 83.38)

Entrez gene

 30846

UniProt

 Q9NZN4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NZN4

Antibodypedia

 EHD2 antibodies

PROTEIN BROWSER
EHD2-001
EHD2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EHD2-001
ENSP00000263277
ENST00000263277
Q9NZN4 [Direct mapping]
EH domain-containing protein 2
A0A024R0S6 [Target identity:100%; Query identity:100%]
EH-domain containing 2, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0006897 [endocytosis]
GO:0007596 [blood coagulation]
GO:0008152 [metabolic process]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016787 [hydrolase activity]
GO:0019898 [extrinsic component of membrane]
GO:0019904 [protein domain specific binding]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0032456 [endocytic recycling]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055038 [recycling endosome membrane]
GO:0070062 [extracellular exosome]
GO:0072659 [protein localization to plasma membrane]
GO:0097320 [membrane tubulation]
GO:1901741 [positive regulation of myoblast fusion]
GO:2001137 [positive regulation of endocytic recycling]
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 543 aa
61.2 kDa 		No 0
EHD2-002
ENSP00000439036
ENST00000538399
Q9NZN4 [Direct mapping]
EH domain-containing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0007596 [blood coagulation]
GO:0008152 [metabolic process]
GO:0010008 [endosome membrane]
GO:0016787 [hydrolase activity]
GO:0019898 [extrinsic component of membrane]
GO:0032456 [endocytic recycling]
GO:0055038 [recycling endosome membrane]
GO:0070062 [extracellular exosome]
GO:0072659 [protein localization to plasma membrane]
GO:0097320 [membrane tubulation]
GO:1901741 [positive regulation of myoblast fusion]
GO:2001137 [positive regulation of endocytic recycling]
Show all
 407 aa
46.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.