Cell atlas - NCAPH2 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

NCAPH2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CELL CYCLE

GENE/PROTEIN

Antibody validation

Dictionary
	Cytokinetic bridge
	Nucleoplasm

Human cell
	Microtubules
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	NCAPH2
Gene description	Non-SMC condensin II complex, subunit H2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytokinetic bridge.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
Additional location	In addition localized to the Cytokinetic bridge (supported)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA067932 , HPA069056
	SHOW MORE

ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytokinetic bridge.

Main location

Nucleoplasm (validated)

Additional location

Cytokinetic bridge (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
HPA067932	CACO-2	Nucleoplasm
HPA067932	CACO-2	Cytokinetic bridge	Intensity	Intensity
HPA067932	HEK 293	Nucleus
HPA067932	U-2 OS	Nucleus
HPA069056	HeLa	Nucleoplasm
HPA069056	HeLa	Cytokinetic bridge	Intensity	Intensity
HPA069056	MCF7	Nucleoplasm
HPA069056	MCF7	Cell Junctions
HPA069056	U-2 OS	Nucleoplasm

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition
Intensity variation	Cytokinetic bridge

GENE INFORMATION
Gene name	NCAPH2 (HGNC Symbol)
Synonyms	384D8-2, CAP-H2, hCAP-H2
Description	Non-SMC condensin II complex, subunit H2 (HGNC Symbol)
Entrez gene summary	This gene encodes one of the non-SMC subunits of the condensin II complex. This complex plays an essential role in mitotic chromosome assembly. Alternate splicing of this gene results in multiple transcript variants.[provided by RefSeq, May 2010]
Chromosome	22
Cytoband	q13.33
Chromosome location (bp)	50508216 - 50523472
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000025770 (version 83.38)
Entrez gene	29781
UniProt	Q6IBW4 (UniProt - Evidence at protein level)
neXtProt	NX_Q6IBW4
Antibodypedia	NCAPH2 antibodies

PROTEIN BROWSER

NCAPH2-001	NCAPH2-003	NCAPH2-006	NCAPH2-009	NCAPH2-012	NCAPH2-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NCAPH2-001 ENSP00000410088 ENST00000420993	Q6IBW4 [Direct mapping] Condensin-2 complex subunit H2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0016020 [membrane] GO:0030261 [chromosome condensation] Show all	605 aa 68.2 kDa	No	0
NCAPH2-003 ENSP00000379050 ENST00000395698	Q6IBW4 [Direct mapping] Condensin-2 complex subunit H2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0016020 [membrane] GO:0030261 [chromosome condensation] Show all	299 aa 32.8 kDa	No	0
NCAPH2-006 ENSP00000379053 ENST00000395701	A0A0A6YYG7 [Direct mapping] Condensin-2 complex subunit H2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		589 aa 66.3 kDa	No	0
NCAPH2-009 ENSP00000299821 ENST00000299821	Q6IBW4 [Direct mapping] Condensin-2 complex subunit H2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0016020 [membrane] GO:0030261 [chromosome condensation] Show all	606 aa 68.3 kDa	No	0
NCAPH2-012 ENSP00000429025 ENST00000523045	E5RJN3 [Direct mapping] Condensin-2 complex subunit H2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		292 aa 32.2 kDa	No	0
NCAPH2-016 ENSP00000430944 ENST00000522304	H0YC55 [Direct mapping] Condensin-2 complex subunit H2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		141 aa 16 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.