Expression of B4GALT7 in cancer - Summary

CANCER ATLAS

Gene description

Xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA042330

GENE INFORMATION
Gene name	B4GALT7 (HGNC Symbol)
Synonyms	beta4Gal-T7, XGALT-1
Description	Xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (HGNC Symbol)
Entrez gene summary	This gene is a member of the beta-1,4-galactosyltransferase (beta4GalT) family. Family members encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose. Each beta4GalT member has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus which then remains uncleaved to function as a transmembrane anchor. The enzyme encoded by this gene attaches the first galactose in the common carbohydrate-protein linkage (GlcA-beta1,3-Gal-beta1,3-Gal-beta1,4-Xyl-beta1-O-Ser) found in proteoglycans. This enzyme differs from other beta4GalTs because it lacks the conserved Cys residues found in beta4GalT1-beta4GalT6 and it is located in cis-Golgi instead of trans-Golgi. Mutations in this gene have been associated with the progeroid form of Ehlers-Danlos syndrome. [provided by RefSeq, Oct 2009]
Chromosome	5
Cytoband	q35.3
Chromosome location (bp)	177600100 - 177610347
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000027847 (version 83.38)
Entrez gene	11285
UniProt	Q9UBV7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UBV7
Antibodypedia	B4GALT7 antibodies

PROTEIN BROWSER

B4GALT7-001	B4GALT7-006	B4GALT7-007	B4GALT7-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
B4GALT7-001 ENSP00000029410 ENST00000029410	Q9UBV7 [Direct mapping] Beta-1,4-galactosyltransferase 7 Xylosylprotein 4-beta-galactosyltransferase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003831 [beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0005975 [carbohydrate metabolic process] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0006029 [proteoglycan metabolic process] GO:0006464 [cellular protein modification process] GO:0006487 [protein N-linked glycosylation] GO:0008378 [galactosyltransferase activity] GO:0016021 [integral component of membrane] GO:0030145 [manganese ion binding] GO:0030203 [glycosaminoglycan metabolic process] GO:0030204 [chondroitin sulfate metabolic process] GO:0031012 [extracellular matrix] GO:0032580 [Golgi cisterna membrane] GO:0043206 [extracellular fibril organization] GO:0044281 [small molecule metabolic process] GO:0046525 [xylosylprotein 4-beta-galactosyltransferase activity] GO:0048147 [negative regulation of fibroblast proliferation] Show all	327 aa 37.4 kDa	No	0
B4GALT7-006 ENSP00000423438 ENST00000510761	D6RA33 [Direct mapping] Beta-1,4-galactosyltransferase 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005975 [carbohydrate metabolic process] GO:0016757 [transferase activity, transferring glycosyl groups] Show all	42 aa 5.1 kDa	No	0
B4GALT7-007 ENSP00000420886 ENST00000505468	D6RDJ8 [Direct mapping] Beta-1,4-galactosyltransferase 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005975 [carbohydrate metabolic process] GO:0016757 [transferase activity, transferring glycosyl groups] Show all	36 aa 4.5 kDa	No	0
B4GALT7-008 ENSP00000423868 ENST00000507061	H0Y9D6 [Direct mapping] Beta-1,4-galactosyltransferase 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005975 [carbohydrate metabolic process] GO:0016757 [transferase activity, transferring glycosyl groups] Show all	77 aa 9.2 kDa	No	0