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B4GALT7

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GENERAL INFORMATION

Gene name

 B4GALT7

Gene description

 Xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 B4GALT7 (HGNC Symbol)

Synonyms

 beta4Gal-T7, XGALT-1

Description

 Xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the beta-1,4-galactosyltransferase (beta4GalT) family. Family members encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose. Each beta4GalT member has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus which then remains uncleaved to function as a transmembrane anchor. The enzyme encoded by this gene attaches the first galactose in the common carbohydrate-protein linkage (GlcA-beta1,3-Gal-beta1,3-Gal-beta1,4-Xyl-beta1-O-Ser) found in proteoglycans. This enzyme differs from other beta4GalTs because it lacks the conserved Cys residues found in beta4GalT1-beta4GalT6 and it is located in cis-Golgi instead of trans-Golgi. Mutations in this gene have been associated with the progeroid form of Ehlers-Danlos syndrome. [provided by RefSeq, Oct 2009]

Chromosome

 5

Cytoband

 q35.3

Chromosome location (bp)

 177600100 - 177610347

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000027847 (version 83.38)

Entrez gene

 11285

UniProt

 Q9UBV7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UBV7

Antibodypedia

 B4GALT7 antibodies

PROTEIN BROWSER
B4GALT7-001
B4GALT7-006
B4GALT7-007
B4GALT7-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
B4GALT7-001
ENSP00000029410
ENST00000029410
Q9UBV7 [Direct mapping]
Beta-1,4-galactosyltransferase 7 Xylosylprotein 4-beta-galactosyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003831 [beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity]
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0005975 [carbohydrate metabolic process]
GO:0006024 [glycosaminoglycan biosynthetic process]
GO:0006029 [proteoglycan metabolic process]
GO:0006464 [cellular protein modification process]
GO:0006487 [protein N-linked glycosylation]
GO:0008378 [galactosyltransferase activity]
GO:0016021 [integral component of membrane]
GO:0030145 [manganese ion binding]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0031012 [extracellular matrix]
GO:0032580 [Golgi cisterna membrane]
GO:0043206 [extracellular fibril organization]
GO:0044281 [small molecule metabolic process]
GO:0046525 [xylosylprotein 4-beta-galactosyltransferase activity]
GO:0048147 [negative regulation of fibroblast proliferation]
Show all
 327 aa
37.4 kDa 		No 0
B4GALT7-006
ENSP00000423438
ENST00000510761
D6RA33 [Direct mapping]
Beta-1,4-galactosyltransferase 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005975 [carbohydrate metabolic process]
GO:0016757 [transferase activity, transferring glycosyl groups]
Show all
 42 aa
5.1 kDa 		No 0
B4GALT7-007
ENSP00000420886
ENST00000505468
D6RDJ8 [Direct mapping]
Beta-1,4-galactosyltransferase 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005975 [carbohydrate metabolic process]
GO:0016757 [transferase activity, transferring glycosyl groups]
Show all
 36 aa
4.5 kDa 		No 0
B4GALT7-008
ENSP00000423868
ENST00000507061
H0Y9D6 [Direct mapping]
Beta-1,4-galactosyltransferase 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005975 [carbohydrate metabolic process]
GO:0016757 [transferase activity, transferring glycosyl groups]
Show all
 77 aa
9.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.