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VRK2

CANCER ATLAS

Gene description

 Vaccinia related kinase 2

Protein class

 Enzymes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Pancreatic cancer

STAINING SUMMARY
HPA047503
CAB046459

GENE INFORMATION

Gene name

 VRK2

Synonyms

Description

 Vaccinia related kinase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity. [provided by RefSeq, Jan 2014]

Chromosome

 2

Cytoband

 p16.1

Chromosome location (bp)

 57907651 - 58159920

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000028116 (version 83.38)

Entrez gene

 7444

UniProt

 Q86Y07 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86Y07

Antibodypedia

 VRK2 antibodies

PROTEIN BROWSER
VRK2-001
VRK2-003
VRK2-004
VRK2-005
VRK2-008
VRK2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
VRK2-001
ENSP00000342381
ENST00000340157
Q86Y07 [Direct mapping]
Serine/threonine-protein kinase VRK2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CK1 Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0008360 [regulation of cell shape]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0019904 [protein domain specific binding]
GO:0031966 [mitochondrial membrane]
GO:0034599 [cellular response to oxidative stress]
GO:0043234 [protein complex]
GO:0043408 [regulation of MAPK cascade]
GO:0046777 [protein autophosphorylation]
GO:2000659 [regulation of interleukin-1-mediated signaling pathway]
Show all
 508 aa
58.1 kDa 		No 1
VRK2-003
ENSP00000404961
ENST00000428021
E7ERS5 [Direct mapping]
Serine/threonine-protein kinase VRK2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006897 [endocytosis]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
Show all
 82 aa
9.5 kDa 		No 0
VRK2-004
ENSP00000402375
ENST00000417641
Q86Y07 [Direct mapping]
Serine/threonine-protein kinase VRK2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CK1 Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0008360 [regulation of cell shape]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0019904 [protein domain specific binding]
GO:0031966 [mitochondrial membrane]
GO:0034599 [cellular response to oxidative stress]
GO:0043234 [protein complex]
GO:0043408 [regulation of MAPK cascade]
GO:0046777 [protein autophosphorylation]
GO:2000659 [regulation of interleukin-1-mediated signaling pathway]
Show all
 396 aa
45 kDa 		No 0
VRK2-005
ENSP00000408002
ENST00000435505
Q86Y07 [Direct mapping]
Serine/threonine-protein kinase VRK2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CK1 Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0008360 [regulation of cell shape]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0019904 [protein domain specific binding]
GO:0031966 [mitochondrial membrane]
GO:0034599 [cellular response to oxidative stress]
GO:0043234 [protein complex]
GO:0043408 [regulation of MAPK cascade]
GO:0046777 [protein autophosphorylation]
GO:2000659 [regulation of interleukin-1-mediated signaling pathway]
Show all
 508 aa
58.1 kDa 		No 1
VRK2-008
ENSP00000398323
ENST00000440705
Q86Y07 [Direct mapping]
Serine/threonine-protein kinase VRK2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CK1 Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0008360 [regulation of cell shape]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0019904 [protein domain specific binding]
GO:0031966 [mitochondrial membrane]
GO:0034599 [cellular response to oxidative stress]
GO:0043234 [protein complex]
GO:0043408 [regulation of MAPK cascade]
GO:0046777 [protein autophosphorylation]
GO:2000659 [regulation of interleukin-1-mediated signaling pathway]
Show all
 485 aa
55.4 kDa 		No 1
VRK2-201
ENSP00000404156
ENST00000412104
Q86Y07 [Direct mapping]
Serine/threonine-protein kinase VRK2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CK1 Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0008360 [regulation of cell shape]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0019904 [protein domain specific binding]
GO:0031966 [mitochondrial membrane]
GO:0034599 [cellular response to oxidative stress]
GO:0043234 [protein complex]
GO:0043408 [regulation of MAPK cascade]
GO:0046777 [protein autophosphorylation]
GO:2000659 [regulation of interleukin-1-mediated signaling pathway]
Show all
 390 aa
44.4 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.