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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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CENPQ
  • TISSUE

  • premium

    CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

Centromere protein Q

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA046634

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several cases of carcinoids, melanomas along with a few cases of gliomas, colorectal, liver and pancreatic cancers showed moderate nuclear/nucleolar positivity. Remaining cancer tissues were weakly stained or negative.

GENE INFORMATION

Gene name

CENPQ (HGNC Symbol)

Synonyms

C6orf139, CENP-Q, FLJ10545

Description

Centromere protein Q (HGNC Symbol)

Entrez gene summary

CENPQ is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]

Chromosome

6

Cytoband

p12.3

Chromosome location (bp)

49463378 - 49493107

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000031691 (version 83.38)

Entrez gene

55166

UniProt

Q7L2Z9 (UniProt - Evidence at protein level)

neXtProt

NX_Q7L2Z9

Antibodypedia

CENPQ antibodies

PROTEIN BROWSER

CENPQ-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CENPQ-001
ENSP00000337289
ENST00000335783
Q7L2Z9 [Direct mapping]
Centromere protein Q
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006334 [nucleosome assembly]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015629 [actin cytoskeleton]
GO:0034080 [CENP-A containing nucleosome assembly]
Show all
268 aa
30.6 kDa
No 0

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The Human Protein Atlas project is funded
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