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Most cancer tissues showed moderate to strong cytoplasmic staining with additional membranous positivity in many cases. Several gliomas, lymphomas, melanomas, hepatocellular carcinomas, renal, skin and testis cancers were weakly stained or negative.
Most cancer tissues showed weak to moderate cytoplasmic staining. A majority of gliomas,lymphomas, lung, prostate, ovarian and breast cancers were negative.
Most cancer tissues displayed weak to moderate cytoplasmic staining sometimes combined with membranous positivity. Fractions of ovarian, urothelial, pancreatic and cervical cancers showed strong positivity. Lymphomas and several hepatocellular carcinomas, renal cancers, gliomas and melanomas were negative.
This gene has been reported in PMID 9403053 as one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alignment of this gene to genomic sequence data suggests that this gene resides on chromosome 2 rather than chromosome 11. [provided by RefSeq, Dec 2008]
