Cell atlas - TSSC1 - The Human Protein Atlas

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TSSC1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Intermediate filaments
	Nucleoli
	Nucleus

Human cell
	Intermediate Filaments
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	TSSC1
Gene description	Tumor suppressing subtransferable candidate 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus & nucleoli. In addition localized to the intermediate filaments.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported), Nucleoli (supported)
Additional location	In addition localized to the Intermediate filaments (approved)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA031231 , HPA031234
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus & nucleoli. In addition localized to the intermediate filaments.

Main location

Nucleus (supported), Nucleoli (supported)

Additional location

Intermediate filaments (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA031231	A-431	Nucleus
		Nucleoli
		Cytosol
HPA031231	U-2 OS	Nucleus
		Nucleoli
		Cytosol
HPA031234	A549	Nucleus
		Nucleoli
		Cytosol
HPA031234	MCF7	Nucleus
HPA031234	MCF7	Nucleoli
HPA031234	U-2 OS	Nucleus
		Nucleoli
		Intermediate filaments
		Cytosol

GENE INFORMATION
Gene name	TSSC1
Synonyms
Description	Tumor suppressing subtransferable candidate 1 (HGNC Symbol)
Entrez gene summary	This gene has been reported in PMID 9403053 as one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alignment of this gene to genomic sequence data suggests that this gene resides on chromosome 2 rather than chromosome 11. [provided by RefSeq, Dec 2008]
Chromosome	2
Cytoband	p25.3
Chromosome location (bp)	3188925 - 3377882
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000032389 (version 83.38)
Entrez gene	7260
UniProt	Q53HC9 (UniProt - Evidence at protein level)
neXtProt	NX_Q53HC9
Antibodypedia	TSSC1 antibodies

PROTEIN BROWSER

TSSC1-001	TSSC1-003	TSSC1-004	TSSC1-007	TSSC1-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TSSC1-001 ENSP00000371559 ENST00000382125	Q53HC9 [Direct mapping] Protein TSSC1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	387 aa 43.6 kDa	No	0
TSSC1-003 ENSP00000381652 ENST00000398659	A8MUM1 [Direct mapping] Protein TSSC1 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	414 aa 46.3 kDa	No	0
TSSC1-004 ENSP00000389080 ENST00000443925	D3YTH5 [Direct mapping] Protein TSSC1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		314 aa 34.9 kDa	No	0
TSSC1-007 ENSP00000393350 ENST00000441271	C9JVR6 [Direct mapping] Protein TSSC1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	178 aa 20.2 kDa	No	0
TSSC1-010 ENSP00000400214 ENST00000444776	C9J0U9 [Direct mapping] Protein TSSC1 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		155 aa 17.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.