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Most cancer tissues showed weak to moderate cytoplasmic immunoreactivity with additional nuclear staining in several cases. Few colorectal and breast cancers were strongly stained.
The enzyme encoded by this gene catalyzes the first mannosylation step in the biosynthesis of lipid-linked oligosaccharides. This gene is mutated in congenital disorder of glycosylation type Ik. [provided by RefSeq, Dec 2008]