Cell atlas - ALG1 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ALG1
Gene description	ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the endoplasmic reticulum. In addition localized to the nucleoli (fibrillar center). Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (approved)
Additional location	In addition localized to the Nucleoli fibrillar center (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA060392
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the endoplasmic reticulum. In addition localized to the nucleoli (fibrillar center). Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Endoplasmic reticulum (approved)

Additional location

Nucleoli fibrillar center (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA060392	HEK 293	Nucleoli fibrillar center
HPA060392	HEK 293	Endoplasmic reticulum
HPA060392	Hep G2	Nucleoli fibrillar center
HPA060392	Hep G2	Endoplasmic reticulum
HPA060392	U-2 OS	No staining

GENE INFORMATION
Gene name	ALG1 (HGNC Symbol)
Synonyms	HMAT1, HMT-1
Description	ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase (HGNC Symbol)
Entrez gene summary	The enzyme encoded by this gene catalyzes the first mannosylation step in the biosynthesis of lipid-linked oligosaccharides. This gene is mutated in congenital disorder of glycosylation type Ik. [provided by RefSeq, Dec 2008]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	5033960 - 5087379
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000033011 (version 83.38)
Entrez gene	56052
UniProt	Q9BT22 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BT22
Antibodypedia	ALG1 antibodies

PROTEIN BROWSER

ALG1-001	ALG1-003	ALG1-010	ALG1-011	ALG1-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALG1-001 ENSP00000262374 ENST00000262374	Q9BT22 [Direct mapping] Chitobiosyldiphosphodolichol beta-mannosyltransferase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000030 [mannosyltransferase activity] GO:0004578 [chitobiosyldiphosphodolichol beta-mannosyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006486 [protein glycosylation] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0009103 [lipopolysaccharide biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0097502 [mannosylation] Show all	464 aa 52.5 kDa	Yes	0
ALG1-003 ENSP00000440019 ENST00000544428	Q9BT22 [Direct mapping] Chitobiosyldiphosphodolichol beta-mannosyltransferase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000030 [mannosyltransferase activity] GO:0004578 [chitobiosyldiphosphodolichol beta-mannosyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006486 [protein glycosylation] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0009103 [lipopolysaccharide biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0097502 [mannosylation] Show all	353 aa 40.3 kDa	No	0
ALG1-010 ENSP00000464700 ENST00000591783	K7EID2 [Direct mapping] Chitobiosyldiphosphodolichol beta-mannosyltransferase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016757 [transferase activity, transferring glycosyl groups] Show all	168 aa 19.4 kDa	No	0
ALG1-011 ENSP00000467538 ENST00000586840	K7EPU3 [Direct mapping] Chitobiosyldiphosphodolichol beta-mannosyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016757 [transferase activity, transferring glycosyl groups] Show all	184 aa 20.2 kDa	Yes	1
ALG1-012 ENSP00000468118 ENST00000588623	Q9BT22 [Direct mapping] Chitobiosyldiphosphodolichol beta-mannosyltransferase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000030 [mannosyltransferase activity] GO:0004578 [chitobiosyldiphosphodolichol beta-mannosyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006486 [protein glycosylation] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0009103 [lipopolysaccharide biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0097502 [mannosylation] Show all	353 aa 40.3 kDa	No	0