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SLC4A7

CANCER ATLAS

Gene description

 Solute carrier family 4, sodium bicarbonate cotransporter, member 7

Protein class

 Predicted membrane proteins, Transporters

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035857
CAB022494

GENE INFORMATION

Gene name

 SLC4A7 (HGNC Symbol)

Synonyms

 NBC3, SBC2, SLC4A6

Description

 Solute carrier family 4, sodium bicarbonate cotransporter, member 7 (HGNC Symbol)

Entrez gene summary

 This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012]

Chromosome

 3

Cytoband

 p24.1

Chromosome location (bp)

 27372721 - 27484420

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000033867 (version 83.38)

Entrez gene

 9497

UniProt

 Q9Y6M7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y6M7

Antibodypedia

 SLC4A7 antibodies

PROTEIN BROWSER
«
SLC4A7-001
SLC4A7-002
SLC4A7-003
SLC4A7-004
SLC4A7-005
SLC4A7-006
SLC4A7-010
SLC4A7-011
SLC4A7-013
SLC4A7-014
SLC4A7-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC4A7-001
ENSP00000295736
ENST00000295736
Q9Y6M7 [Direct mapping]
Sodium bicarbonate cotransporter 3
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006820 [anion transport]
GO:0007601 [visual perception]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0021747 [cochlear nucleus development]
GO:0031410 [cytoplasmic vesicle]
GO:0032420 [stereocilium]
GO:0035725 [sodium ion transmembrane transport]
GO:0045202 [synapse]
GO:0046666 [retinal cell programmed cell death]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:0060117 [auditory receptor cell development]
GO:0060219 [camera-type eye photoreceptor cell differentiation]
GO:0061299 [retina vasculature morphogenesis in camera-type eye]
GO:0098656 [anion transmembrane transport]
Show all
 1214 aa
136 kDa 		No >9
SLC4A7-002
ENSP00000416368
ENST00000428386
Q9Y6M7 [Direct mapping]
Sodium bicarbonate cotransporter 3
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0032420 [stereocilium]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:0060117 [auditory receptor cell development]
GO:0098656 [anion transmembrane transport]
Show all
 1090 aa
123.1 kDa 		No >9
SLC4A7-003
ENSP00000411031
ENST00000419036
H7C3C4 [Direct mapping]
Anion exchange protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0060117 [auditory receptor cell development]
GO:0098656 [anion transmembrane transport]
Show all
 801 aa
89.8 kDa 		No >9
SLC4A7-004
ENSP00000407382
ENST00000455077
Q9Y6M7 [Direct mapping]
Sodium bicarbonate cotransporter 3
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0032420 [stereocilium]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:0060117 [auditory receptor cell development]
GO:0098656 [anion transmembrane transport]
Show all
 1131 aa
127.4 kDa 		No >9
SLC4A7-005
ENSP00000394252
ENST00000437179
Q9Y6M7 [Direct mapping]
Sodium bicarbonate cotransporter 3
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0032420 [stereocilium]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:0060117 [auditory receptor cell development]
GO:0098656 [anion transmembrane transport]
Show all
 1095 aa
123.4 kDa 		No >9
SLC4A7-006
ENSP00000414797
ENST00000440156
Q9Y6M7 [Direct mapping]
Sodium bicarbonate cotransporter 3
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0032420 [stereocilium]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:0060117 [auditory receptor cell development]
GO:0098656 [anion transmembrane transport]
Show all
 1246 aa
139.3 kDa 		No >9
SLC4A7-010
ENSP00000406804
ENST00000445684
E9PFN4 [Direct mapping]
Anion exchange protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0060117 [auditory receptor cell development]
GO:0098656 [anion transmembrane transport]
Show all
 1210 aa
135.3 kDa 		No >9
SLC4A7-011
ENSP00000406605
ENST00000446700
Q9Y6M7 [Direct mapping]
Sodium bicarbonate cotransporter 3
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0032420 [stereocilium]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:0060117 [auditory receptor cell development]
GO:0098656 [anion transmembrane transport]
Show all
 1206 aa
134.9 kDa 		No >9
SLC4A7-013
ENSP00000388703
ENST00000428179
C9JRP1 [Direct mapping]
Anion exchange protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0060117 [auditory receptor cell development]
GO:0098656 [anion transmembrane transport]
Show all
 1051 aa
118.5 kDa 		No >9
SLC4A7-014
ENSP00000390394
ENST00000454389
Q9Y6M7 [Direct mapping]
Sodium bicarbonate cotransporter 3
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0032420 [stereocilium]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:0060117 [auditory receptor cell development]
GO:0098656 [anion transmembrane transport]
Show all
 1259 aa
140.8 kDa 		No >9
SLC4A7-201
ENSP00000401949
ENST00000425128
A0A0A0MST8 [Direct mapping]
Anion exchange protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0060117 [auditory receptor cell development]
GO:0098656 [anion transmembrane transport]
Show all
 1201 aa
134.6 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.