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Most cancer cells showed moderate to strong, often granular, cytoplasmic immunoreactivity. A majority of testicular and renal cancers were weakly stained or negative.
Most cancers exhibited moderate granular cytoplasmic positivity. Several cases of prostate cancers along with papillary adenocarcinomas of thyroid showed strong positivity. The majority of renal, skin and liver cancers were weakly stained or negative.
GENE INFORMATION
Gene name
PEX3
Synonyms
Description
Peroxisomal biogenesis factor 3 (HGNC Symbol)
Entrez gene summary
The product of this gene is involved in peroxisome biosynthesis and integrity. It assembles membrane vesicles before the matrix proteins are translocated. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause Zellweger syndrome (ZWS). [provided by RefSeq, Oct 2008]
