Cell atlas - PEX3 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

PEX3

premium

TISSUE

premium

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm
	Peroxisomes

Human cell
	Nucleoplasm
	Vesicles

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	PEX3
Gene description	Peroxisomal biogenesis factor 3
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm & peroxisome.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Peroxisomes (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA042830
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm & peroxisome.

Main location

Nucleoplasm (approved), Peroxisomes (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA042830	A-431	Nucleoplasm
	HPA042830	A-431	Peroxisomes
	HPA042830	U-2 OS	Nucleoplasm
	HPA042830	U-2 OS	Peroxisomes
	HPA042830	U-251 MG	Nucleoplasm
	HPA042830	U-251 MG	Peroxisomes

GENE INFORMATION
Gene name	PEX3
Synonyms
Description	Peroxisomal biogenesis factor 3 (HGNC Symbol)
Entrez gene summary	The product of this gene is involved in peroxisome biosynthesis and integrity. It assembles membrane vesicles before the matrix proteins are translocated. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause Zellweger syndrome (ZWS). [provided by RefSeq, Oct 2008]
Chromosome	6
Cytoband	q24.2
Chromosome location (bp)	143450807 - 143490010
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000034693 (version 83.38)
Entrez gene	8504
UniProt	P56589 (UniProt - Evidence at protein level)
neXtProt	NX_P56589
Antibodypedia	PEX3 antibodies

PROTEIN BROWSER

PEX3-001	PEX3-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PEX3-001 ENSP00000356563 ENST00000367591	P56589 [Direct mapping] Peroxisomal biogenesis factor 3 Show all	Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002230 [positive regulation of defense response to virus by host] GO:0003333 [amino acid transmembrane transport] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005777 [peroxisome] GO:0005778 [peroxisomal membrane] GO:0005779 [integral component of peroxisomal membrane] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0007031 [peroxisome organization] GO:0008289 [lipid binding] GO:0015171 [amino acid transmembrane transporter activity] GO:0016020 [membrane] GO:0016557 [peroxisome membrane biogenesis] GO:0032994 [protein-lipid complex] GO:0043231 [intracellular membrane-bounded organelle] GO:0043234 [protein complex] GO:0045046 [protein import into peroxisome membrane] GO:0046983 [protein dimerization activity] GO:0055085 [transmembrane transport] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	373 aa 42.1 kDa	No	1
PEX3-002 ENSP00000356564 ENST00000367592	Q7Z6V3 [Direct mapping] Peroxisomal biogenesis factor 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005779 [integral component of peroxisomal membrane] GO:0007031 [peroxisome organization] GO:0015171 [amino acid transmembrane transporter activity] Show all	182 aa 20.5 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.