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STAP1

CANCER ATLAS

Gene description

 Signal transducing adaptor family member 1

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA038529

GENE INFORMATION

Gene name

 STAP1 (HGNC Symbol)

Synonyms

 BRDG1, STAP-1

Description

 Signal transducing adaptor family member 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene contains a proline-rich region, a pleckstrin homology (PH) domain, and a region in the carboxy terminal half with similarity to the Src Homology 2 (SH2) domain. This protein is a substrate of tyrosine-protein kinase Tec, and its interaction with tyrosine-protein kinase Tec is phosphorylation-dependent. This protein is thought to participate in a positive feedback loop by upregulating the activity of tyrosine-protein kinase Tec. Variants of this gene have been associated with autosomal-dominant hypercholesterolemia (ADH), which is characterized by elevated low-density lipoprotein cholesterol levels and in increased risk of coronary vascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Chromosome

 4

Cytoband

 q13.2

Chromosome location (bp)

 67558728 - 67607337

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000035720 (version 83.38)

Entrez gene

 26228

UniProt

 Q9ULZ2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9ULZ2

Antibodypedia

 STAP1 antibodies

PROTEIN BROWSER
STAP1-001
STAP1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STAP1-001
ENSP00000265404
ENST00000265404
Q9ULZ2 [Direct mapping]
Signal-transducing adaptor protein 1
A0A024RD91 [Target identity:100%; Query identity:100%]
BCR downstream signaling 1, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0001784 [phosphotyrosine binding]
GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005157 [macrophage colony-stimulating factor receptor binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0010628 [positive regulation of gene expression]
GO:0010760 [negative regulation of macrophage chemotaxis]
GO:0019901 [protein kinase binding]
GO:0030971 [receptor tyrosine kinase binding]
GO:0042326 [negative regulation of phosphorylation]
GO:0043234 [protein complex]
GO:0050861 [positive regulation of B cell receptor signaling pathway]
GO:0060100 [positive regulation of phagocytosis, engulfment]
GO:0071222 [cellular response to lipopolysaccharide]
GO:1900028 [negative regulation of ruffle assembly]
GO:1902227 [negative regulation of macrophage colony-stimulating factor signaling pathway]
GO:1903980 [positive regulation of microglial cell activation]
GO:1903997 [positive regulation of non-membrane spanning protein tyrosine kinase activity]
GO:1904140 [negative regulation of microglial cell migration]
GO:1904151 [positive regulation of microglial cell mediated cytotoxicity]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 295 aa
34.3 kDa 		No 0
STAP1-002
ENSP00000379527
ENST00000396225
Q9ULZ2 [Direct mapping]
Signal-transducing adaptor protein 1
A0A024RD91 [Target identity:100%; Query identity:100%]
BCR downstream signaling 1, isoform CRA_a
Show all
Predicted intracellular proteins
Show all
GO:0001784 [phosphotyrosine binding]
GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0010628 [positive regulation of gene expression]
GO:0010760 [negative regulation of macrophage chemotaxis]
GO:0019901 [protein kinase binding]
GO:0042326 [negative regulation of phosphorylation]
GO:0043234 [protein complex]
GO:0050861 [positive regulation of B cell receptor signaling pathway]
GO:0060100 [positive regulation of phagocytosis, engulfment]
GO:0071222 [cellular response to lipopolysaccharide]
GO:1900028 [negative regulation of ruffle assembly]
GO:1902227 [negative regulation of macrophage colony-stimulating factor signaling pathway]
GO:1903980 [positive regulation of microglial cell activation]
GO:1903997 [positive regulation of non-membrane spanning protein tyrosine kinase activity]
GO:1904151 [positive regulation of microglial cell mediated cytotoxicity]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 295 aa
34.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.