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STAP1

GENERAL INFORMATION

Gene name

 STAP1

Gene description

 Signal transducing adaptor family member 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (lymph node, tonsil, spleen, appendix, kidney)
GTEx:Tissue enhanced (spleen, small intestine)
FANTOM5:Tissue enhanced (appendix, spleen, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in a subset of immune cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA038529
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (lymph node, tonsil, spleen, appendix, kidney)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, spleen, tonsil)

GENE INFORMATION

Gene name

 STAP1 (HGNC Symbol)

Synonyms

 BRDG1, STAP-1

Description

 Signal transducing adaptor family member 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene contains a proline-rich region, a pleckstrin homology (PH) domain, and a region in the carboxy terminal half with similarity to the Src Homology 2 (SH2) domain. This protein is a substrate of tyrosine-protein kinase Tec, and its interaction with tyrosine-protein kinase Tec is phosphorylation-dependent. This protein is thought to participate in a positive feedback loop by upregulating the activity of tyrosine-protein kinase Tec. Variants of this gene have been associated with autosomal-dominant hypercholesterolemia (ADH), which is characterized by elevated low-density lipoprotein cholesterol levels and in increased risk of coronary vascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Chromosome

 4

Cytoband

 q13.2

Chromosome location (bp)

 67558728 - 67607337

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000035720 (version 83.38)

Entrez gene

 26228

UniProt

 Q9ULZ2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9ULZ2

Antibodypedia

 STAP1 antibodies

PROTEIN BROWSER
STAP1-001
STAP1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STAP1-001
ENSP00000265404
ENST00000265404
Q9ULZ2 [Direct mapping]
Signal-transducing adaptor protein 1
A0A024RD91 [Target identity:100%; Query identity:100%]
BCR downstream signaling 1, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0001784 [phosphotyrosine binding]
GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005157 [macrophage colony-stimulating factor receptor binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0010628 [positive regulation of gene expression]
GO:0010760 [negative regulation of macrophage chemotaxis]
GO:0019901 [protein kinase binding]
GO:0030971 [receptor tyrosine kinase binding]
GO:0042326 [negative regulation of phosphorylation]
GO:0043234 [protein complex]
GO:0050861 [positive regulation of B cell receptor signaling pathway]
GO:0060100 [positive regulation of phagocytosis, engulfment]
GO:0071222 [cellular response to lipopolysaccharide]
GO:1900028 [negative regulation of ruffle assembly]
GO:1902227 [negative regulation of macrophage colony-stimulating factor signaling pathway]
GO:1903980 [positive regulation of microglial cell activation]
GO:1903997 [positive regulation of non-membrane spanning protein tyrosine kinase activity]
GO:1904140 [negative regulation of microglial cell migration]
GO:1904151 [positive regulation of microglial cell mediated cytotoxicity]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 295 aa
34.3 kDa 		No 0
STAP1-002
ENSP00000379527
ENST00000396225
Q9ULZ2 [Direct mapping]
Signal-transducing adaptor protein 1
A0A024RD91 [Target identity:100%; Query identity:100%]
BCR downstream signaling 1, isoform CRA_a
Show all
Predicted intracellular proteins
Show all
GO:0001784 [phosphotyrosine binding]
GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0010628 [positive regulation of gene expression]
GO:0010760 [negative regulation of macrophage chemotaxis]
GO:0019901 [protein kinase binding]
GO:0042326 [negative regulation of phosphorylation]
GO:0043234 [protein complex]
GO:0050861 [positive regulation of B cell receptor signaling pathway]
GO:0060100 [positive regulation of phagocytosis, engulfment]
GO:0071222 [cellular response to lipopolysaccharide]
GO:1900028 [negative regulation of ruffle assembly]
GO:1902227 [negative regulation of macrophage colony-stimulating factor signaling pathway]
GO:1903980 [positive regulation of microglial cell activation]
GO:1903997 [positive regulation of non-membrane spanning protein tyrosine kinase activity]
GO:1904151 [positive regulation of microglial cell mediated cytotoxicity]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 295 aa
34.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.