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Most tumor cells showed weak to moderate cytoplasmic and nuclear staining. The majority of cases of colorectal, lung, skin and gastric cancers were negative.
Cancer tissues displayed weak to moderate cytoplasmic and/or nuclear positivity. Few cases of endometrial, breast, liver, colorectal, prostate, pancreatic and ovarian cancers were strongly stained. Several cases of lymphomas, cervical, testicular, stomach and renal cancers were negative.
GENE INFORMATION
Gene name
HOXC8 (HGNC Symbol)
Synonyms
HOX3, HOX3A
Description
Homeobox C8 (HGNC Symbol)
Entrez gene summary
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders. [provided by RefSeq, Jul 2008]
