Expression of BEST2 in cancer - Summary

CANCER ATLAS

Gene description

Bestrophin 2

Protein class

Predicted intracellular proteins, Predicted membrane proteins, Transporters

Protein evidence

Evidence at transcript level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA046229

GENE INFORMATION
Gene name	BEST2 (HGNC Symbol)
Synonyms	FLJ20132, VMD2L1
Description	Bestrophin 2 (HGNC Symbol)
Entrez gene summary	This gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene structure with highly conserved exon-intron boundaries, but with distinct 3' ends. Bestrophins are transmembrane proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif. Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy. The bestrophin 2 gene is mainly expressed in the retinal pigment epithelium and colon. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.13
Chromosome location (bp)	12751702 - 12758458
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000039987 (version 83.38)
Entrez gene	54831
UniProt	Q8NFU1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8NFU1
Antibodypedia	BEST2 antibodies

PROTEIN BROWSER

BEST2-001	BEST2-002	BEST2-003	BEST2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BEST2-001 ENSP00000447203 ENST00000553030	Q8NFU1 [Direct mapping] Bestrophin-2 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0003674 [molecular_function] GO:0005254 [chloride channel activity] GO:0005887 [integral component of plasma membrane] GO:0005929 [cilium] GO:0007608 [sensory perception of smell] GO:0008150 [biological_process] GO:0034707 [chloride channel complex] GO:0051899 [membrane depolarization] GO:1902476 [chloride transmembrane transport] Show all	509 aa 57.1 kDa	No	4
BEST2-002 ENSP00000448310 ENST00000549706	Q8NFU1 [Direct mapping] Bestrophin-2 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0003674 [molecular_function] GO:0005254 [chloride channel activity] GO:0005887 [integral component of plasma membrane] GO:0005929 [cilium] GO:0007608 [sensory perception of smell] GO:0008150 [biological_process] GO:0034707 [chloride channel complex] GO:0051899 [membrane depolarization] GO:1902476 [chloride transmembrane transport] Show all	509 aa 57.1 kDa	No	4
BEST2-003 ENSP00000449403 ENST00000552539	H0YIH1 [Direct mapping] Bestrophin-2 Show all	Predicted intracellular proteins Show all		78 aa 8.9 kDa	No	0
BEST2-201 ENSP00000042931 ENST00000042931	Q8NFU1 [Direct mapping] Bestrophin-2 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0003674 [molecular_function] GO:0005254 [chloride channel activity] GO:0005887 [integral component of plasma membrane] GO:0005929 [cilium] GO:0007608 [sensory perception of smell] GO:0008150 [biological_process] GO:0034707 [chloride channel complex] GO:0051899 [membrane depolarization] GO:1902476 [chloride transmembrane transport] Show all	509 aa 57.1 kDa	No	4