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BEST2

GENERAL INFORMATION

Gene name

 BEST2

Gene description

 Bestrophin 2

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (colon, rectum)
GTEx:Group enriched (colon, small intestine, skin)
FANTOM5:Tissue enhanced (retina, colon)

Protein evidence

 Evidence at transcript level

Protein expression

 Cytoplasmic expression in goblet cells is colon and rectum

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA046229
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (colon, rectum)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (colon, small intestine, skin)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (retina, colon)

GENE INFORMATION

Gene name

 BEST2 (HGNC Symbol)

Synonyms

 FLJ20132, VMD2L1

Description

 Bestrophin 2 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene structure with highly conserved exon-intron boundaries, but with distinct 3' ends. Bestrophins are transmembrane proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif. Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy. The bestrophin 2 gene is mainly expressed in the retinal pigment epithelium and colon. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.13

Chromosome location (bp)

 12751702 - 12758458

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000039987 (version 83.38)

Entrez gene

 54831

UniProt

 Q8NFU1 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8NFU1

Antibodypedia

 BEST2 antibodies

PROTEIN BROWSER
BEST2-001
BEST2-002
BEST2-003
BEST2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BEST2-001
ENSP00000447203
ENST00000553030
Q8NFU1 [Direct mapping]
Bestrophin-2
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Show all
GO:0003674 [molecular_function]
GO:0005254 [chloride channel activity]
GO:0005887 [integral component of plasma membrane]
GO:0005929 [cilium]
GO:0007608 [sensory perception of smell]
GO:0008150 [biological_process]
GO:0034707 [chloride channel complex]
GO:0051899 [membrane depolarization]
GO:1902476 [chloride transmembrane transport]
Show all
 509 aa
57.1 kDa 		No 4
BEST2-002
ENSP00000448310
ENST00000549706
Q8NFU1 [Direct mapping]
Bestrophin-2
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Show all
GO:0003674 [molecular_function]
GO:0005254 [chloride channel activity]
GO:0005887 [integral component of plasma membrane]
GO:0005929 [cilium]
GO:0007608 [sensory perception of smell]
GO:0008150 [biological_process]
GO:0034707 [chloride channel complex]
GO:0051899 [membrane depolarization]
GO:1902476 [chloride transmembrane transport]
Show all
 509 aa
57.1 kDa 		No 4
BEST2-003
ENSP00000449403
ENST00000552539
H0YIH1 [Direct mapping]
Bestrophin-2
Show all
Predicted intracellular proteins
Show all
 78 aa
8.9 kDa 		No 0
BEST2-201
ENSP00000042931
ENST00000042931
Q8NFU1 [Direct mapping]
Bestrophin-2
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Show all
GO:0003674 [molecular_function]
GO:0005254 [chloride channel activity]
GO:0005887 [integral component of plasma membrane]
GO:0005929 [cilium]
GO:0007608 [sensory perception of smell]
GO:0008150 [biological_process]
GO:0034707 [chloride channel complex]
GO:0051899 [membrane depolarization]
GO:1902476 [chloride transmembrane transport]
Show all
 509 aa
57.1 kDa 		No 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.