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AIFM2

CANCER ATLAS

Gene description

 Apoptosis-inducing factor, mitochondrion-associated, 2

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042309

GENE INFORMATION

Gene name

 AIFM2 (HGNC Symbol)

Synonyms

 AMID, FLJ14497, PRG3

Description

 Apoptosis-inducing factor, mitochondrion-associated, 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. [provided by RefSeq, Nov 2010]

Chromosome

 10

Cytoband

 q22.1

Chromosome location (bp)

 70098223 - 70132934

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000042286 (version 83.38)

Entrez gene

 84883

UniProt

 Q9BRQ8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BRQ8

Antibodypedia

 AIFM2 antibodies

PROTEIN BROWSER
AIFM2-001
AIFM2-002
AIFM2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AIFM2-001
ENSP00000312370
ENST00000307864
Q9BRQ8 [Direct mapping]
Apoptosis-inducing factor 2
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004174 [electron-transferring-flavoprotein dehydrogenase activity]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0008137 [NADH dehydrogenase (ubiquinone) activity]
GO:0008637 [apoptotic mitochondrial changes]
GO:0016021 [integral component of membrane]
GO:0016491 [oxidoreductase activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
Show all
 373 aa
40.5 kDa 		No 0
AIFM2-002
ENSP00000362345
ENST00000373248
Q9BRQ8 [Direct mapping]
Apoptosis-inducing factor 2
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004174 [electron-transferring-flavoprotein dehydrogenase activity]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0008137 [NADH dehydrogenase (ubiquinone) activity]
GO:0008637 [apoptotic mitochondrial changes]
GO:0016021 [integral component of membrane]
GO:0016491 [oxidoreductase activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
Show all
 373 aa
40.5 kDa 		No 0
AIFM2-201
ENSP00000478931
ENST00000613322
Q9BRQ8 [Direct mapping]
Apoptosis-inducing factor 2
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004174 [electron-transferring-flavoprotein dehydrogenase activity]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0008137 [NADH dehydrogenase (ubiquinone) activity]
GO:0008637 [apoptotic mitochondrial changes]
GO:0016021 [integral component of membrane]
GO:0016491 [oxidoreductase activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
Show all
 373 aa
40.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.