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CAPG

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GENERAL INFORMATION

Gene name

 CAPG

Gene description

 Capping protein (actin filament), gelsolin-like

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus.

RNA cell category

 Cell line enhanced (HMC-1, CAPAN-2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (validated)

Single-cell variation

 Single-cell variation in protein expression observed.

siRNA

 The location(s) are Validated based on siRNA mediated gene silencing.

DATA RELIABILITY

Reliability score

 Validated based on 1 antibody.
HPA019080
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ASSAYS
RNA expression
Human cells
siRNA

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HMC-1, CAPAN-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus.

Main location

 Nucleus (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA019080 A-431 Nucleus Intensity
HPA019080 U-2 OS Nucleus Intensity
HPA019080 U-251 MG Nucleus Intensity

siRNA VALIDATION
 

Relative fluorescence intensity (RFI)

Antibody

 HPA019080

siRNA validation

 Validated: Significant downregulation > 25% by one siRNA.

Analysis performed in

 Nuclear region of segmented cells in 10x-images

siRNA 1

RFI

 38%

p-value

 0.015
 

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail 10x

Thumbnail 40x

Antibody

Sample

Cell line
HPA019080 scrambled U-2 OS
HPA019080 siRNA 1 U-2 OS

GENE INFORMATION

Gene name

 CAPG (HGNC Symbol)

Synonyms

 AFCP, MCP

Description

 Capping protein (actin filament), gelsolin-like (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2012]

Chromosome

 2

Cytoband

 p11.2

Chromosome location (bp)

 85394748 - 85418432

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000042493 (version 83.38)

Entrez gene

 822

UniProt

 P40121 (UniProt - Evidence at protein level)

neXtProt

 NX_P40121

Antibodypedia

 CAPG antibodies

PROTEIN BROWSER
CAPG-001
CAPG-002
CAPG-003
CAPG-004
CAPG-005
CAPG-008
CAPG-011
CAPG-012
CAPG-016

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CAPG-001
ENSP00000263867
ENST00000263867
P40121 [Direct mapping]
Macrophage-capping protein
V9HW69 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 66
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005814 [centriole]
GO:0006461 [protein complex assembly]
GO:0008290 [F-actin capping protein complex]
GO:0019904 [protein domain specific binding]
GO:0030031 [cell projection assembly]
GO:0032403 [protein complex binding]
GO:0042470 [melanosome]
GO:0051016 [barbed-end actin filament capping]
GO:0070062 [extracellular exosome]
GO:0072686 [mitotic spindle]
GO:0090543 [Flemming body]
Show all
 348 aa
38.5 kDa 		No 0
CAPG-002
ENSP00000386965
ENST00000409724
P40121 [Direct mapping]
Macrophage-capping protein
V9HW69 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 66
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005814 [centriole]
GO:0006461 [protein complex assembly]
GO:0008290 [F-actin capping protein complex]
GO:0019904 [protein domain specific binding]
GO:0032403 [protein complex binding]
GO:0042470 [melanosome]
GO:0051016 [barbed-end actin filament capping]
GO:0070062 [extracellular exosome]
GO:0072686 [mitotic spindle]
GO:0090543 [Flemming body]
Show all
 348 aa
38.5 kDa 		No 0
CAPG-003
ENSP00000386315
ENST00000409670
P40121 [Direct mapping]
Macrophage-capping protein
V9HW69 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 66
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005814 [centriole]
GO:0006461 [protein complex assembly]
GO:0008290 [F-actin capping protein complex]
GO:0019904 [protein domain specific binding]
GO:0032403 [protein complex binding]
GO:0042470 [melanosome]
GO:0051016 [barbed-end actin filament capping]
GO:0070062 [extracellular exosome]
GO:0072686 [mitotic spindle]
GO:0090543 [Flemming body]
Show all
 348 aa
38.5 kDa 		No 0
CAPG-004
ENSP00000387063
ENST00000409921
P40121 [Direct mapping]
Macrophage-capping protein
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005814 [centriole]
GO:0006461 [protein complex assembly]
GO:0008290 [F-actin capping protein complex]
GO:0019904 [protein domain specific binding]
GO:0032403 [protein complex binding]
GO:0042470 [melanosome]
GO:0051016 [barbed-end actin filament capping]
GO:0070062 [extracellular exosome]
GO:0072686 [mitotic spindle]
GO:0090543 [Flemming body]
Show all
 333 aa
36.9 kDa 		No 0
CAPG-005
ENSP00000391923
ENST00000439385
E7ENU9 [Direct mapping]
Macrophage-capping protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005634 [nucleus]
GO:0051016 [barbed-end actin filament capping]
Show all
 253 aa
27.8 kDa 		No 0
CAPG-008
ENSP00000398232
ENST00000447219
E7ENU9 [Direct mapping]
Macrophage-capping protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005634 [nucleus]
GO:0051016 [barbed-end actin filament capping]
Show all
 253 aa
27.8 kDa 		No 0
CAPG-011
ENSP00000403330
ENST00000449030
E7ENU9 [Direct mapping]
Macrophage-capping protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005634 [nucleus]
GO:0051016 [barbed-end actin filament capping]
Show all
 253 aa
27.8 kDa 		No 0
CAPG-012
ENSP00000386596
ENST00000409275
B8ZZL6 [Direct mapping]
Macrophage-capping protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005634 [nucleus]
GO:0051016 [barbed-end actin filament capping]
Show all
 218 aa
24.1 kDa 		No 0
CAPG-016
ENSP00000397381
ENST00000453973
H7C0X8 [Direct mapping]
Macrophage-capping protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0051016 [barbed-end actin filament capping]
Show all
 103 aa
11.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.