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A subset of tumor cells in some gliomas showed moderate to strong cytoplasmic staining. Several cases of renal cancers displayed moderate to strong cytoplasmic and membranous positivity. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
ADRB1 (HGNC Symbol)
Synonyms
ADRB1R
Description
Adrenoceptor beta 1 (HGNC Symbol)
Entrez gene summary
The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008]