Expression of ARAP2 in cancer - Summary

CANCER ATLAS

Gene description

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA035925

GENE INFORMATION
Gene name	ARAP2 (HGNC Symbol)
Synonyms	CENTD1, PARX
Description	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008]
Chromosome	4
Cytoband	p14
Chromosome location (bp)	35948221 - 36244509
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000047365 (version 83.38)
Entrez gene	116984
UniProt	Q8WZ64 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WZ64
Antibodypedia	ARAP2 antibodies

PROTEIN BROWSER

ARAP2-001	ARAP2-004	ARAP2-005	ARAP2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARAP2-001 ENSP00000302895 ENST00000303965	Q8WZ64 [Direct mapping] Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	1704 aa 193.5 kDa	No	0
ARAP2-004 ENSP00000422731 ENST00000506189	D6RAD6 [Direct mapping] Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	47 aa 5.3 kDa	No	0
ARAP2-005 ENSP00000423886 ENST00000511416	D6RC39 [Direct mapping] Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		50 aa 6 kDa	No	0
ARAP2-201 ENSP00000481036 ENST00000618163	A0A0C4DGW1 [Direct mapping] Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0007165 [signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	863 aa 98.7 kDa	No	0