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ARAP2

GENERAL INFORMATION

Gene name

 ARAP2

Gene description

 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in several different tissue types.

DATA RELIABILITY

Data reliability
description

 Caution, Splice and/or transcript discrepancy exists. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA035925
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ARAP2 (HGNC Symbol)

Synonyms

 CENTD1, PARX

Description

 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008]

Chromosome

 4

Cytoband

 p14

Chromosome location (bp)

 35948221 - 36244509

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000047365 (version 83.38)

Entrez gene

 116984

UniProt

 Q8WZ64 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WZ64

Antibodypedia

 ARAP2 antibodies

PROTEIN BROWSER
ARAP2-001
ARAP2-004
ARAP2-005
ARAP2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARAP2-001
ENSP00000302895
ENST00000303965
Q8WZ64 [Direct mapping]
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 1704 aa
193.5 kDa 		No 0
ARAP2-004
ENSP00000422731
ENST00000506189
D6RAD6 [Direct mapping]
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 47 aa
5.3 kDa 		No 0
ARAP2-005
ENSP00000423886
ENST00000511416
D6RC39 [Direct mapping]
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 50 aa
6 kDa 		No 0
ARAP2-201
ENSP00000481036
ENST00000618163
A0A0C4DGW1 [Direct mapping]
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0007165 [signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 863 aa
98.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.