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GOPC

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GENERAL INFORMATION

Gene name

 GOPC

Gene description

 Golgi-associated PDZ and coiled-coil motif containing

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the Golgi apparatus. In addition localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Golgi apparatus (validated)

Additional location

 In addition localized to the Cytosol (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA019477 , HPA024018
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the Golgi apparatus. In addition localized to the cytosol.

Main location

 Golgi apparatus (validated)

Additional location

 Cytosol (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA019477 A-431 Golgi apparatus Intensity
HPA019477 U-2 OS Golgi apparatus
Cytosol
HPA019477 U-251 MG Golgi apparatus
HPA024018 A-431 Golgi apparatus
HPA024018 U-2 OS Golgi apparatus
HPA024018 U-251 MG Golgi apparatus

GENE INFORMATION

Gene name

 GOPC (HGNC Symbol)

Synonyms

 CAL, dJ94G16.2, FIG, GOPC1, PIST

Description

 Golgi-associated PDZ and coiled-coil motif containing (HGNC Symbol)

Entrez gene summary

 This gene encodes a Golgi protein with a PDZ domain. The PDZ domain is globular and proteins which contain them bind other proteins through short motifs near the C-termini. Mice which are deficient in the orthologous protein have globozoospermia and are infertile. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Chromosome

 6

Cytoband

 q22.1

Chromosome location (bp)

 117560269 - 117602542

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000047932 (version 83.38)

Entrez gene

 57120

UniProt

 Q9HD26 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HD26

Antibodypedia

 GOPC antibodies

PROTEIN BROWSER
GOPC-001
GOPC-002
GOPC-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GOPC-001
ENSP00000052569
ENST00000052569
Q9HD26 [Direct mapping]
Golgi-associated PDZ and coiled-coil motif-containing protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006893 [Golgi to plasma membrane transport]
GO:0007264 [small GTPase mediated signal transduction]
GO:0014069 [postsynaptic density]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0030140 [trans-Golgi network transport vesicle]
GO:0030425 [dendrite]
GO:0030660 [Golgi-associated vesicle membrane]
GO:0043004 [cytoplasmic sequestering of CFTR protein]
GO:0043234 [protein complex]
GO:0044325 [ion channel binding]
GO:0045176 [apical protein localization]
GO:0045211 [postsynaptic membrane]
GO:0051260 [protein homooligomerization]
Show all
 454 aa
49.7 kDa 		No 0
GOPC-002
ENSP00000357484
ENST00000368498
Q9HD26 [Direct mapping]
Golgi-associated PDZ and coiled-coil motif-containing protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006893 [Golgi to plasma membrane transport]
GO:0007264 [small GTPase mediated signal transduction]
GO:0014069 [postsynaptic density]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0030140 [trans-Golgi network transport vesicle]
GO:0030425 [dendrite]
GO:0030660 [Golgi-associated vesicle membrane]
GO:0043004 [cytoplasmic sequestering of CFTR protein]
GO:0043234 [protein complex]
GO:0044325 [ion channel binding]
GO:0045176 [apical protein localization]
GO:0045211 [postsynaptic membrane]
GO:0051260 [protein homooligomerization]
Show all
 462 aa
50.5 kDa 		No 0
GOPC-201
ENSP00000445690
ENST00000535237
F5H1Y4 [Direct mapping]
Golgi-associated PDZ and coiled-coil motif containing protein transcript variant 3; Golgi-associated PDZ and coiled-coil motif-containing protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
Show all
 407 aa
44.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.