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GUCA1A
  • TISSUE

  • CELL

  • CANCER

TISSUE ATLAS PRIMARY DATA
MOUSE BRAIN

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

GUCA1A

Gene description

Guanylate cyclase activator 1A (retina)

Protein class

Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (testis)
GTEx:Tissue enhanced (testis)
FANTOM5:Group enriched (retina, testis)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in retina, mainly in photoreceptor layer.

DATA RELIABILITY

Data reliability
description

External characterization data supports antibody staining but no internal RNA data available for correlation.

Reliability score

Supported based on 1 antibody.
HPA005561
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Eye
N/A
Retina
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Retina

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinRetinaNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin051015202530TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin0510152025RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (retina, testis)
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina050100150200250300Tags Per Million

GENE INFORMATION

Gene name

GUCA1A (HGNC Symbol)

Synonyms

C6orf131, COD3, CORD14, dJ139D8.6, GCAP, GCAP1, GUCA, GUCA1

Description

Guanylate cyclase activator 1A (retina) (HGNC Symbol)

Entrez gene summary

This gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein encoded by this gene, guanylyl cyclase activating protein 1 (GCAP1), mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3); a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations; causing the constitutive activation of RetGC1 and, presumably, increased cell death. This gene is expressed in retina and spermatagonia. [provided by RefSeq, Feb 2009]

Chromosome

6

Cytoband

p21.1

Chromosome location (bp)

42155406 - 42180056

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000048545 (version 83.38)

Entrez gene

2978

UniProt

P43080 (UniProt - Evidence at protein level)

neXtProt

NX_P43080

Antibodypedia

GUCA1A antibodies

PROTEIN BROWSER

GUCA1A-001
GUCA1A-002
GUCA1A-003
GUCA1A-004
GUCA1A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GUCA1A-001
ENSP00000362049
ENST00000372958
P43080 [Direct mapping]
Guanylyl cyclase-activating protein 1
Show all
Predicted intracellular proteins
Disease related genes
Show all
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007603 [phototransduction, visible light]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0097381 [photoreceptor disc membrane]
Show all
201 aa
22.9 kDa
No 0
GUCA1A-002
ENSP00000377784
ENST00000394237
P43080 [Direct mapping]
Guanylyl cyclase-activating protein 1
Show all
Predicted intracellular proteins
Disease related genes
Show all
GO:0001750 [photoreceptor outer segment]
GO:0001917 [photoreceptor inner segment]
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007601 [visual perception]
GO:0007602 [phototransduction]
GO:0007603 [phototransduction, visible light]
GO:0008048 [calcium sensitive guanylate cyclase activator activity]
GO:0016020 [membrane]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0030249 [guanylate cyclase regulator activity]
GO:0030828 [positive regulation of cGMP biosynthetic process]
GO:0031282 [regulation of guanylate cyclase activity]
GO:0031284 [positive regulation of guanylate cyclase activity]
GO:0097381 [photoreceptor disc membrane]
Show all
201 aa
22.9 kDa
No 0
GUCA1A-003
ENSP00000053469
ENST00000053469
P43080 [Direct mapping]
Guanylyl cyclase-activating protein 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007603 [phototransduction, visible light]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0097381 [photoreceptor disc membrane]
Show all
201 aa
22.9 kDa
No 0
GUCA1A-004
ENSP00000388438
ENST00000418175
A6PVH5 [Direct mapping]
Guanylyl cyclase-activating protein 1
Show all
Predicted intracellular proteins
Show all
GO:0005509 [calcium ion binding]
Show all
88 aa
10.2 kDa
No 0
GUCA1A-201
ENSP00000437476
ENST00000541991
A0A0A0MTF5 [Direct mapping]
Guanylyl cyclase-activating protein 1
Show all
Predicted intracellular proteins
Show all
GO:0005509 [calcium ion binding]
Show all
205 aa
23.5 kDa
No 0

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