Expression of H6PD in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

Protein class

Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA004824	HPA005440

GENE INFORMATION
Gene name	H6PD (HGNC Symbol)
Synonyms	GDH
Description	Hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) (HGNC Symbol)
Entrez gene summary	There are 2 forms of glucose-6-phosphate dehydrogenase. G form is X-linked and H form, encoded by this gene, is autosomally linked. This H form shows activity with other hexose-6-phosphates, especially galactose-6-phosphate, whereas the G form is specific for glucose-6-phosphate. Both forms are present in most tissues, but H form is not found in red cells. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.22
Chromosome location (bp)	9234775 - 9271337
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000049239 (version 83.38)
Entrez gene	9563
UniProt	O95479 (UniProt - Evidence at protein level)
neXtProt	NX_O95479
Antibodypedia	H6PD antibodies

PROTEIN BROWSER

H6PD-001	H6PD-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
H6PD-001 ENSP00000366620 ENST00000377403	O95479 [Direct mapping] GDH/6PGL endoplasmic bifunctional protein Glucose 1-dehydrogenase 6-phosphogluconolactonase Show all	Enzymes ENZYME proteins Oxidoreductases Hydrolases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004345 [glucose-6-phosphate dehydrogenase activity] GO:0005788 [endoplasmic reticulum lumen] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006098 [pentose-phosphate shunt] GO:0017057 [6-phosphogluconolactonase activity] GO:0047936 [glucose 1-dehydrogenase [NAD(P)] activity] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] Show all	791 aa 88.9 kDa	Yes	0
H6PD-003 ENSP00000473348 ENST00000602477	R4GMU1 [Direct mapping] GDH/6PGL endoplasmic bifunctional protein Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004345 [glucose-6-phosphate dehydrogenase activity] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006098 [pentose-phosphate shunt] GO:0006739 [NADP metabolic process] GO:0017057 [6-phosphogluconolactonase activity] GO:0030246 [carbohydrate binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] GO:0097305 [response to alcohol] Show all	802 aa 90.2 kDa	Yes	0