Fields »
ABOUT
HELP
BLOG
H6PD

GENERAL INFORMATION

Gene name

 H6PD

Gene description

 Hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA004824 , HPA005440
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 H6PD (HGNC Symbol)

Synonyms

 GDH

Description

 Hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) (HGNC Symbol)

Entrez gene summary

 There are 2 forms of glucose-6-phosphate dehydrogenase. G form is X-linked and H form, encoded by this gene, is autosomally linked. This H form shows activity with other hexose-6-phosphates, especially galactose-6-phosphate, whereas the G form is specific for glucose-6-phosphate. Both forms are present in most tissues, but H form is not found in red cells. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.22

Chromosome location (bp)

 9234775 - 9271337

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000049239 (version 83.38)

Entrez gene

 9563

UniProt

 O95479 (UniProt - Evidence at protein level)

neXtProt

 NX_O95479

Antibodypedia

 H6PD antibodies

PROTEIN BROWSER
H6PD-001
H6PD-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
H6PD-001
ENSP00000366620
ENST00000377403
O95479 [Direct mapping]
GDH/6PGL endoplasmic bifunctional protein Glucose 1-dehydrogenase 6-phosphogluconolactonase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004345 [glucose-6-phosphate dehydrogenase activity]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006098 [pentose-phosphate shunt]
GO:0017057 [6-phosphogluconolactonase activity]
GO:0047936 [glucose 1-dehydrogenase [NAD(P)] activity]
GO:0050661 [NADP binding]
GO:0055114 [oxidation-reduction process]
Show all
 791 aa
88.9 kDa 		Yes 0
H6PD-003
ENSP00000473348
ENST00000602477
R4GMU1 [Direct mapping]
GDH/6PGL endoplasmic bifunctional protein
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004345 [glucose-6-phosphate dehydrogenase activity]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006098 [pentose-phosphate shunt]
GO:0006739 [NADP metabolic process]
GO:0017057 [6-phosphogluconolactonase activity]
GO:0030246 [carbohydrate binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0050661 [NADP binding]
GO:0055114 [oxidation-reduction process]
GO:0097305 [response to alcohol]
Show all
 802 aa
90.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.