Tissue expression of PLEKHA5 - Summary - The Human Protein Atlas

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PLEKHA5

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PLEKHA5
Gene description	Pleckstrin homology domain containing, family A member 5
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Mixed
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and membranous expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA035923 , HPA035924
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	PLEKHA5 (HGNC Symbol)
Synonyms	FLJ10667, KIAA1686, PEPP2
Description	Pleckstrin homology domain containing, family A member 5 (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	p12.3
Chromosome location (bp)	19129752 - 19376400
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000052126 (version 83.38)
Entrez gene	54477
UniProt	Q9HAU0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HAU0
Antibodypedia	PLEKHA5 antibodies

PROTEIN BROWSER

PLEKHA5-001	PLEKHA5-002	PLEKHA5-004	PLEKHA5-005	PLEKHA5-006	PLEKHA5-009	PLEKHA5-011	PLEKHA5-201	PLEKHA5-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLEKHA5-001 ENSP00000439673 ENST00000538714	Q9HAU0 [Direct mapping] Pleckstrin homology domain-containing family A member 5 A0A024RAY7 [Target identity:100%; Query identity:100%] Pleckstrin homology domain containing, family A member 5, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005545 [1-phosphatidylinositol binding] GO:0008150 [biological_process] GO:0016020 [membrane] Show all	1174 aa 134.3 kDa	No	0
PLEKHA5-002 ENSP00000299275 ENST00000299275	Q9HAU0 [Direct mapping] Pleckstrin homology domain-containing family A member 5 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005545 [1-phosphatidylinositol binding] GO:0008150 [biological_process] GO:0016020 [membrane] Show all	1116 aa 127.5 kDa	No	0
PLEKHA5-004 ENSP00000404296 ENST00000429027	Q9HAU0 [Direct mapping] Pleckstrin homology domain-containing family A member 5 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005545 [1-phosphatidylinositol binding] GO:0005829 [cytosol] GO:0008150 [biological_process] GO:0010314 [phosphatidylinositol-5-phosphate binding] GO:0016020 [membrane] GO:0032266 [phosphatidylinositol-3-phosphate binding] GO:0061458 [reproductive system development] GO:0070273 [phosphatidylinositol-4-phosphate binding] GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding] Show all	1282 aa 146.9 kDa	No	0
PLEKHA5-005 ENSP00000440371 ENST00000536974	B4DJX4 [Direct mapping] Pleckstrin homology domain-containing family A member 5; cDNA FLJ59284, highly similar to Pleckstrin homology domain-containing family A member 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		977 aa 111.9 kDa	No	0
PLEKHA5-006 ENSP00000443553 ENST00000538972	H0YGJ6 [Direct mapping] Pleckstrin homology domain-containing family A member 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		397 aa 45.2 kDa	No	0
PLEKHA5-009 ENSP00000446308 ENST00000538305	F5H1X3 [Direct mapping] Pleckstrin homology domain-containing family A member 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		118 aa 13.6 kDa	No	0
PLEKHA5-011 ENSP00000439396 ENST00000540972	Q9HAU0 [Direct mapping] Pleckstrin homology domain-containing family A member 5 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005545 [1-phosphatidylinositol binding] GO:0008150 [biological_process] GO:0016020 [membrane] Show all	76 aa 8.7 kDa	No	0
PLEKHA5-201 ENSP00000400411 ENST00000424268	Q9HAU0 [Direct mapping] Pleckstrin homology domain-containing family A member 5 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005545 [1-phosphatidylinositol binding] GO:0008150 [biological_process] GO:0016020 [membrane] Show all	1098 aa 125.5 kDa	No	0
PLEKHA5-202 ENSP00000440611 ENST00000539256	A0JP02 [Direct mapping] PLEKHA5 protein; Pleckstrin homology domain-containing family A member 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		874 aa 99.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.