Expression of PRSS8 in cancer - Summary

CANCER ATLAS

Gene description

Protease, serine, 8

Protein class

Enzymes, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA030436

GENE INFORMATION
Gene name	PRSS8
Synonyms
Description	Protease, serine, 8 (HGNC Symbol)
Entrez gene summary	This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. The proprotein is cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. It is active on peptide linkages involving the carboxyl group of lysine or arginine. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	p11.2
Chromosome location (bp)	31131433 - 31135762
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000052344 (version 83.38)
Entrez gene	5652
UniProt	Q16651 (UniProt - Evidence at protein level)
neXtProt	NX_Q16651
Antibodypedia	PRSS8 antibodies

PROTEIN BROWSER

PRSS8-001	PRSS8-003	PRSS8-004	PRSS8-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRSS8-001 ENSP00000319730 ENST00000317508	Q16651 [Direct mapping] Prostasin Prostasin light chain Prostasin heavy chain Show all	Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0010765 [positive regulation of sodium ion transport] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	343 aa 36.4 kDa	Yes	1
PRSS8-003 ENSP00000457750 ENST00000568261	Q16651 [Direct mapping] Prostasin Prostasin light chain Prostasin heavy chain Show all	Enzymes Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	289 aa 30.5 kDa	Yes	0
PRSS8-004 ENSP00000458056 ENST00000567797	H3BVC8 [Direct mapping] Prostasin Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	108 aa 11.3 kDa	Yes	0
PRSS8-005 ENSP00000457673 ENST00000567531	H3BUJ8 [Direct mapping] Prostasin Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	195 aa 20.5 kDa	Yes	0