Cell atlas - PRSS8 - The Human Protein Atlas

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PRSS8

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	PRSS8
Gene description	Protease, serine, 8
Protein class	Enzymes Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (BEWO, SK-BR-3, CACO-2, hTCEpi, CAPAN-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA063533
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BEWO, SK-BR-3, CACO-2, hTCEpi, CAPAN-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA063533	CACO-2	Cytosol
	HPA063533	U-2 OS	Cytosol

GENE INFORMATION
Gene name	PRSS8
Synonyms
Description	Protease, serine, 8 (HGNC Symbol)
Entrez gene summary	This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. The proprotein is cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. It is active on peptide linkages involving the carboxyl group of lysine or arginine. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	p11.2
Chromosome location (bp)	31131433 - 31135762
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000052344 (version 83.38)
Entrez gene	5652
UniProt	Q16651 (UniProt - Evidence at protein level)
neXtProt	NX_Q16651
Antibodypedia	PRSS8 antibodies

PROTEIN BROWSER

PRSS8-001	PRSS8-003	PRSS8-004	PRSS8-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRSS8-001 ENSP00000319730 ENST00000317508	Q16651 [Direct mapping] Prostasin Prostasin light chain Prostasin heavy chain Show all	Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0010765 [positive regulation of sodium ion transport] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	343 aa 36.4 kDa	Yes	1
PRSS8-003 ENSP00000457750 ENST00000568261	Q16651 [Direct mapping] Prostasin Prostasin light chain Prostasin heavy chain Show all	Enzymes Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	289 aa 30.5 kDa	Yes	0
PRSS8-004 ENSP00000458056 ENST00000567797	H3BVC8 [Direct mapping] Prostasin Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	108 aa 11.3 kDa	Yes	0
PRSS8-005 ENSP00000457673 ENST00000567531	H3BUJ8 [Direct mapping] Prostasin Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	195 aa 20.5 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.